ROBO1 roundabout guidance receptor 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: ROBO1provided by VGNC
Official Full Name: roundabout guidance receptor 1provided by VGNC
Primary source: VGNC:VGNC:76713
See related: Ensembl:ENSMMUG00000002327
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	2	NC_041755.1 (192125380..193292671)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	2	NC_027894.1 (3157157..4395169, complement)

Chromosome 2 - NC_041755.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-77115 (e-PCR)
- UniSTS:76843

fi28b09.x1 (e-PCR)
- UniSTS:197176

RH120182 (e-PCR)
- UniSTS:133176

Robo1 (e-PCR), detects polymorphism
- UniSTS:498508

SHGC-35216 (e-PCR)
- UniSTS:13921

D3S2500 (e-PCR)
- UniSTS:150116

D3S2511 (e-PCR)
- UniSTS:150127

D3S2512 (e-PCR)
- UniSTS:150128

D3S2513 (e-PCR)
- UniSTS:150129

SHGC-77117 (e-PCR)
- UniSTS:66689

SHGC-111359 (e-PCR)
- UniSTS:168326

SHGC-111365 (e-PCR)
- UniSTS:168331

SHGC-112294 (e-PCR)
- UniSTS:168596

D3S4492 (e-PCR)
- UniSTS:474524

D3S3 (e-PCR)
- UniSTS:146848

D3S3474E (e-PCR)
- UniSTS:154020

D3S3962 (e-PCR)
- UniSTS:60849

SHGC-110573 (e-PCR)
- UniSTS:167911

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon midline choice point recognition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: roundabout homolog 1

Names: roundabout, axon guidance receptor, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041755.1 Reference Mmul_10 Primary Assembly

Range

192125380..193292671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015129091.2 → XP_014984577.1 roundabout homolog 1 isoform X3

UniProtKB/TrEMBL

G7MJT0

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_015129082.2 → XP_014984568.1 roundabout homolog 1 isoform X1

UniProtKB/TrEMBL

G7MJT0

Conserved Domains (7) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:781 → 864

fn3; Fibronectin type III domain

pfam13927
Location:457 → 531

Ig_3; Immunoglobulin domain
XM_015129106.2 → XP_014984592.1 roundabout homolog 1 isoform X7

UniProtKB/TrEMBL

G7MJT0

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_015129109.2 → XP_014984595.1 roundabout homolog 1 isoform X8

UniProtKB/TrEMBL

G7MJT0

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_015129085.2 → XP_014984571.1 roundabout homolog 1 isoform X2

UniProtKB/TrEMBL

F7C6B8, G7MJT0

Related

ENSMMUP00000003117.3, ENSMMUT00000003301.4

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:365 → 454

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:561 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:778 → 864

fn3; Fibronectin type III domain

cl11960
Location:459 → 533

Ig; Immunoglobulin domain
XM_028844724.1 → XP_028700557.1 roundabout homolog 1 isoform X1

UniProtKB/TrEMBL

G7MJT0

Conserved Domains (7) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:781 → 864

fn3; Fibronectin type III domain

pfam13927
Location:457 → 531

Ig_3; Immunoglobulin domain
XM_015129097.2 → XP_014984583.1 roundabout homolog 1 isoform X4

UniProtKB/TrEMBL

H9FY57

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cl11960
Location:423 → 497

Ig; Immunoglobulin domain
XM_015129103.2 → XP_014984589.1 roundabout homolog 1 isoform X6

UniProtKB/TrEMBL

H9FY56

Related

ENSMMUP00000003118.4, ENSMMUT00000003302.4

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cl11960
Location:423 → 497

Ig; Immunoglobulin domain
XM_015129115.2 → XP_014984601.1 roundabout homolog 1 isoform X9

UniProtKB/TrEMBL

H9FY56

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cl11960
Location:423 → 497

Ig; Immunoglobulin domain
XM_015129100.2 → XP_014984586.1 roundabout homolog 1 isoform X5

UniProtKB/TrEMBL

H9FY57

Related

ENSMMUP00000054133.2, ENSMMUT00000061533.2

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:326 → 415

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:522 → 608

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:739 → 825

fn3; Fibronectin type III domain

cl11960
Location:420 → 494

Ig; Immunoglobulin domain