IL4 interleukin 4 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: IL4provided by VGNC
Official Full Name: interleukin 4provided by VGNC
Primary source: VGNC:VGNC:73729
Locus tag: EGK_16838
See related: Ensembl:ENSMMUG00000003133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	6	NC_041759.1 (130115269..130123589)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	6	NC_027898.1 (130365401..130374493)

Chromosome 6 - NC_041759.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exposure of Microglia to Interleukin-4 Represses NF-kappaB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines.
Title: Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
Title: Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Title: Social temperament and lymph node innervation.

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General gene information

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Markers

REN71236 (e-PCR)
- UniSTS:396036

REN71237 (e-PCR)
- UniSTS:396037

REN71238 (e-PCR)
- UniSTS:396038

REN71239 (e-PCR)
- UniSTS:396039

REN71240 (e-PCR)
- UniSTS:396040

REN71247 (e-PCR)
- UniSTS:396047

REN71250 (e-PCR)
- UniSTS:396050

REN71251 (e-PCR)
- UniSTS:396051

REN71254 (e-PCR)
- UniSTS:396054

REN71258 (e-PCR)
- UniSTS:396058

REN71259 (e-PCR)
- UniSTS:396059

REN71261 (e-PCR)
- UniSTS:396061

ECD12380 (e-PCR)
- UniSTS:293413

GDB:456299 (e-PCR)
- UniSTS:157483

stSG601441 (e-PCR)
- UniSTS:444246

stSG601444 (e-PCR)
- UniSTS:444249

stSG601445 (e-PCR)
- UniSTS:444250

stSG601446 (e-PCR)
- UniSTS:444251

stSG601447 (e-PCR)
- UniSTS:444252

ECD22217 (e-PCR)
- UniSTS:303205

ECD07045 (e-PCR)
- UniSTS:288103

ECD08604 (e-PCR)
- UniSTS:289652

IL4 (e-PCR), detects polymorphism
- UniSTS:479899

GDB:180247 (e-PCR)
- UniSTS:155063

GDB:207332 (e-PCR)
- UniSTS:156119

ECD19759 (e-PCR)
- UniSTS:300763

ECD02519 (e-PCR)
- UniSTS:283616

ECD01760 (e-PCR)
- UniSTS:282861

REN71219 (e-PCR)
- UniSTS:396019

REN71220 (e-PCR)
- UniSTS:396020

REN71222 (e-PCR)
- UniSTS:396022

REN71223 (e-PCR)
- UniSTS:396023

ECD08735 (e-PCR)
- UniSTS:289783

REN71224 (e-PCR)
- UniSTS:396024

REN71225 (e-PCR)
- UniSTS:396025

REN71227 (e-PCR)
- UniSTS:396027

REN71228 (e-PCR)
- UniSTS:396028

REN71229 (e-PCR)
- UniSTS:396029

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell costimulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activation of Janus kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info	PubMed
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T-helper 17 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of eosinophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgE isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mononuclear cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-4

Names: B-cell stimulatory factor 1; BSF-1; IL-4; lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.