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    SESN1 sestrin 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700232, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SESN1provided by VGNC
    Official Full Name
    sestrin 1provided by VGNC
    Primary source
    VGNC:VGNC:77289
    Locus tag
    EGK_15463
    See related
    Ensembl:ENSMMUG00000018232
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SESN1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (12675435..12782237, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (158826926..158934016)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37a-like Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene armadillo repeat containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene centrosomal protein 57 like 1 Neighboring gene putative uncharacterized protein C6orf183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sestrin-1
    XP_014993094.1
    XP_014993095.1
    XP_014993097.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      12675435..12782237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015137608.2 → XP_014993094.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5S6RBQ4, A0A8J8Y4R1, F7E0H5, G7MQY5, H9F854
      Related
      ENSMMUP00000023971.4, ENSMMUT00000025624.4
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 550
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_015137609.2 → XP_014993095.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5S6RBQ4, A0A8J8Y4R1, F7E0H5, G7MQY5, H9F854
      Related
      ENSMMUP00000077453.1, ENSMMUT00000092716.1
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 550
      PA26; PA26 p53-induced protein (sestrin)

    3. XM_015137611.2 → XP_014993097.1  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AL42, F7D7D8
      Related
      ENSMMUP00000032977.1, ENSMMUT00000039917.3
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)
    Nucleotide Protein
    Heading Accession and Version

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