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    DGKA diacylglycerol kinase alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710559, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DGKAprovided by VGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:71780
    Locus tag
    EGK_03778
    See related
    Ensembl:ENSMMUG00000018814
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DGKA in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (55486216..55508747)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (54659046..54681961)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase P pseudogene Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    diacylglycerol kinase, alpha 80kDa
    XP_001112709.2
    XP_015007417.1
    XP_028685422.1
    XP_028685423.1
    XP_028685424.1
    XP_028685425.1
    XP_028685426.1
    XP_028685427.1
    XP_028685428.1
    XP_028685429.1
    XP_028685430.1
    XP_028685432.1
    XP_028685433.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      55486216..55508747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028829595.1 → XP_028685428.1  diacylglycerol kinase alpha isoform X6

      UniProtKB/TrEMBL
      F7BND6
      Conserved Domains (6) summary
      smart00045
      Location:566 → 747
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:424 → 545
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:247 → 307
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:316 → 377
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl08302
      Location:114 → 229
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_001112709.4 → XP_001112709.2  diacylglycerol kinase alpha isoform X8

      UniProtKB/TrEMBL
      A0A5F8AM07, A0A8J8XWB0, F7BND6, G7N7A5
      Related
      ENSMMUP00000078950.1, ENSMMUT00000086895.1
      Conserved Domains (5) summary
      smart00045
      Location:520 → 701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378 → 499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      pfam00130
      Location:206 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_028829591.1 → XP_028685424.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZGN9
      Conserved Domains (5) summary
      smart00045
      Location:619 → 800
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:477 → 598
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:6 → 163
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl08302
      Location:167 → 282
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:305 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. XM_028829597.1 → XP_028685430.1  diacylglycerol kinase alpha isoform X6

      UniProtKB/TrEMBL
      F7BND6
      Conserved Domains (6) summary
      smart00045
      Location:566 → 747
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:424 → 545
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:247 → 307
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:316 → 377
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl08302
      Location:114 → 229
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. XM_028829596.1 → XP_028685429.1  diacylglycerol kinase alpha isoform X6

      UniProtKB/TrEMBL
      F7BND6
      Conserved Domains (6) summary
      smart00045
      Location:566 → 747
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:424 → 545
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:247 → 307
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:316 → 377
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl08302
      Location:114 → 229
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. XM_028829599.1 → XP_028685432.1  diacylglycerol kinase alpha isoform X8

      UniProtKB/TrEMBL
      A0A5F8AM07, A0A8J8XWB0, F7BND6, G7N7A5
      Conserved Domains (5) summary
      smart00045
      Location:520 → 701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378 → 499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      pfam00130
      Location:206 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    7. XM_028829600.1 → XP_028685433.1  diacylglycerol kinase alpha isoform X9

      UniProtKB/TrEMBL
      H9F8X8
      Conserved Domains (5) summary
      smart00045
      Location:379 → 560
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237 → 358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20799
      Location:60 → 120
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:129 → 190
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
      cl08302
      Location:1 → 42
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    8. XM_028829592.1 → XP_028685425.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZGN9
      Related
      ENSMMUP00000063604.1, ENSMMUT00000079358.1
      Conserved Domains (5) summary
      smart00045
      Location:619 → 800
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:477 → 598
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:6 → 163
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl08302
      Location:167 → 282
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:305 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    9. XM_015151931.2 → XP_015007417.1  diacylglycerol kinase alpha isoform X7

      UniProtKB/TrEMBL
      F6ZHF9, F7BND6
      Related
      ENSMMUP00000024762.4, ENSMMUT00000026454.4
      Conserved Domains (7) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:416 → 749
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:244 → 292
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:153 → 217
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    10. XM_028829594.1 → XP_028685427.1  diacylglycerol kinase alpha isoform X5

      UniProtKB/TrEMBL
      F7BND6
      Conserved Domains (5) summary
      smart00045
      Location:604 → 785
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:462 → 583
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:44 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl08302
      Location:152 → 267
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:290 → 338
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    11. XM_028829589.1 → XP_028685422.1  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZGN9
      Conserved Domains (5) summary
      smart00045
      Location:657 → 838
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:515 → 636
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:44 → 201
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl08302
      Location:205 → 320
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:343 → 391
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    12. XM_028829590.1 → XP_028685423.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZGN9
      Conserved Domains (5) summary
      smart00045
      Location:640 → 821
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:505 → 619
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam14513
      Location:44 → 201
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl08302
      Location:205 → 320
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:343 → 391
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    13. XM_028829593.1 → XP_028685426.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZGN9
      Conserved Domains (5) summary
      smart00045
      Location:611 → 792
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:469 → 590
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:205 → 274
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:44 → 201
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      pfam00130
      Location:297 → 345
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
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