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    PDE8B phosphodiesterase 8B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712674, updated on 5-Mar-2024

    Summary

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    Gene symbol
    PDE8B
    Gene description
    phosphodiesterase 8B
    See related
    Ensembl:ENSMMUG00000021358
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE8B in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (73911957..74255819)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (73892355..74104933)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA47 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene zinc finger BED-type containing 3 Neighboring gene uncharacterized LOC114678825 Neighboring gene WD repeat domain 41 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene orthopedia homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      73911957..74255819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028849529.1 → XP_028705362.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

      UniProtKB/TrEMBL
      G7MUT5
      Related
      ENSMMUP00000061042.2, ENSMMUT00000077405.2
      Conserved Domains (3) summary
      COG2202
      Location:24 → 254
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156 → 253
      PAS_9; PAS domain

    2. XM_028849528.1 → XP_028705361.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

      UniProtKB/TrEMBL
      G7MUT5
      Related
      ENSMMUP00000048595.2, ENSMMUT00000076848.2
      Conserved Domains (3) summary
      COG2202
      Location:47 → 274
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:513 → 760
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:179 → 276
      PAS_9; PAS domain

    3. XM_028849527.1 → XP_028705360.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

      Conserved Domains (4) summary
      COG2202
      Location:401 → 612
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:848 → 1039
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:514 → 611
      PAS_9; PAS domain

    4. XM_015140308.2 → XP_014995794.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

      Conserved Domains (4) summary
      COG2202
      Location:382 → 551
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:798 → 1045
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:514 → 567
      PAS_9; PAS domain

    5. XM_015140305.2 → XP_014995791.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

      UniProtKB/TrEMBL
      A0A1D5QWH4
      Related
      ENSMMUP00000052404.2, ENSMMUT00000064805.2
      Conserved Domains (4) summary
      COG2202
      Location:382 → 612
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:848 → 1095
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:514 → 611
      PAS_9; PAS domain

    6. XM_015140306.2 → XP_014995792.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

      Conserved Domains (4) summary
      COG2202
      Location:381 → 611
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:847 → 1094
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:513 → 610
      PAS_9; PAS domain

    7. XM_015140307.2 → XP_014995793.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

      UniProtKB/TrEMBL
      A0A1D5RFF8
      Related
      ENSMMUP00000059052.2, ENSMMUT00000069291.2
      Conserved Domains (2) summary
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:801 → 1048
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. XM_015140309.2 → XP_014995795.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

      UniProtKB/TrEMBL
      F7DG52
      Related
      ENSMMUP00000028138.4, ENSMMUT00000030066.4
      Conserved Domains (3) summary
      PHA02597
      Location:392 → 545
      30.2; hypothetical protein; Provisional
      pfam08629
      Location:235 → 281
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:751 → 998
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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