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    MAMU-DQA1 major histocompatibility complex, class II, DQ alpha 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 720582, updated on 9-Nov-2023

    Summary

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    Gene symbol
    MAMU-DQA1
    Gene description
    major histocompatibility complex, class II, DQ alpha 1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    Mamu-DQA
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    Genomic context

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    See MAMU-DQA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136846809..136853258, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) Unplaced Scaffold NW_015076612.1 (20744..27962, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class II, DO beta Neighboring gene major histocompatibility complex, class II, DQ beta 1 Neighboring gene MHC class II antigen Neighboring gene HLA class II histocompatibility antigen, DRB1-10 beta chain-like Neighboring gene HLA class II histocompatibility antigen, DRB1-3 chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two novel Mamu-DQA1 alleles of rhesus monkeys. Sauermann U, et al. Tissue Antigens, 1995 Nov. PMID 8838354
    2. PCR-RFLP-based DQA1 typing of rhesus monkeys: sequence analysis of a new allele. Christ R, et al. Tissue Antigens, 1994 Oct. PMID 7871525
    3. Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populations. Doxiadis GG, et al. Immunogenetics, 2003 Nov. PMID 14566434
    4. DQ-haplotype analysis in rhesus macaques: implications for the evolution of these genes. Sauermann U. Tissue Antigens, 1998 Dec. PMID 9894854
    5. Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles. Kenter M, et al. Immunogenetics, 1992. PMID 1612647

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DQ alpha 1
    Names
    MHC class II antigen DQ alpha 1 chain
    MHC class II protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134295.1 → NP_001127767.1  major histocompatibility complex, class II, DQ alpha 1 precursor

      See identical proteins and their annotated locations for NP_001127767.1

      Status: PROVISIONAL

      Source sequence(s)
      EF544138
      UniProtKB/TrEMBL
      A0A0F7W048, A5JL31
      Conserved Domains (3) summary
      cd05767
      Location:112 → 205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:30 → 108
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:203 → 254
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      136846809..136853258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846901.1 → XP_028702734.1  major histocompatibility complex, class II, DQ alpha 1 isoform X1

      UniProtKB/TrEMBL
      A0A024J532
      Conserved Domains (2) summary
      cd05767
      Location:112 → 205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 → 107
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    2. XM_028846899.1 → XP_028702732.1  major histocompatibility complex, class II, DQ alpha 1 isoform X1

      UniProtKB/TrEMBL
      A0A024J532
      Conserved Domains (2) summary
      cd05767
      Location:112 → 205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 → 107
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    Nucleotide Protein
    Heading Accession and Version

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