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    COMT catechol-O-methyltransferase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712548, updated on 17-Aug-2024

    Summary

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    Official Symbol
    COMTprovided by VGNC
    Official Full Name
    catechol-O-methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:107781
    See related
    Ensembl:ENSMMUG00000054068
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See COMT in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (32673713..32702017, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (61669742..61699553)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA mir-185 Neighboring gene ARVCF delta catenin family member Neighboring gene thioredoxin reductase 2 Neighboring gene G protein subunit beta 1 like Neighboring gene retrotransposon Gag like 10 Neighboring gene T-box transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables catechol O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catecholamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catechol O-methyltransferase
    NP_001247941.1
    XP_015005207.2
    XP_015005208.2
    XP_015005209.2
    XP_015005210.2
    XP_015005211.2
    XP_028683178.1
    XP_028683179.1
    XP_028683180.1
    XP_028683181.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261012.2 → NP_001247941.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_001247941.1

      Status: PROVISIONAL

      Source sequence(s)
      JV046207
      UniProtKB/TrEMBL
      F6QFW9, I2CT60
      Related
      ENSMMUP00000074706.1, ENSMMUT00000101642.1
      Conserved Domains (1) summary
      cl17173
      Location:66 → 227
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      32673713..32702017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015149725.2 → XP_015005211.2  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    2. XM_015149723.2 → XP_015005209.2  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    3. XM_015149721.2 → XP_015005207.2  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Related
      ENSMMUP00000078293.1, ENSMMUT00000088651.1
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    4. XM_028827348.1 → XP_028683181.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Related
      ENSMMUP00000067362.1, ENSMMUT00000091430.1
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    5. XM_015149724.2 → XP_015005210.2  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Related
      ENSMMUP00000074558.1, ENSMMUT00000101370.1
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    6. XM_015149722.2 → XP_015005208.2  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    7. XM_028827345.1 → XP_028683178.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Related
      ENSMMUP00000066668.1, ENSMMUT00000102660.1
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    8. XM_028827346.1 → XP_028683179.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Related
      ENSMMUP00000080728.1, ENSMMUT00000103331.1
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    9. XM_028827347.1 → XP_028683180.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A5F8A4J5, I2CT60
      Conserved Domains (1) summary
      COG4122
      Location:95 → 263
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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