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    KPNA1 karyopherin subunit alpha 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 692082, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KPNA1provided by VGNC
    Official Full Name
    karyopherin subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:74199
    Locus tag
    EGK_11357
    See related
    Ensembl:ENSMMUG00000016379
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See KPNA1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (153799332..153892206)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (43652434..43744225, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene uncharacterized LOC114676419 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene family with sequence similarity 162 member A Neighboring gene WD repeat domain 5B Neighboring gene mitochondrial matrix import factor 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin subunit alpha-5
    Names
    importin subunit alpha-1
    karyopherin alpha 1 (importin alpha 5)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261170.2 → NP_001248099.1  importin subunit alpha-5

      See identical proteins and their annotated locations for NP_001248099.1

      Status: PROVISIONAL

      Source sequence(s)
      JV047008
      UniProtKB/TrEMBL
      A0A1D5QJL1, A0A8J8YPE6, F7G2W5, G7MKJ8
      Related
      ENSMMUP00000021507.2, ENSMMUT00000022995.4
      Conserved Domains (3) summary
      COG5064
      Location:33 → 516
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:88 → 116
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      153799332..153892206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843053.1 → XP_028698886.1  importin subunit alpha-5 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QJL1, A0A8J8YPE6, F7G2W5, G7MKJ8
      Related
      ENSMMUP00000044545.2, ENSMMUT00000075577.2
      Conserved Domains (3) summary
      COG5064
      Location:33 → 516
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:88 → 116
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]

    2. XM_028843051.1 → XP_028698884.1  importin subunit alpha-5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJL1
      Conserved Domains (2) summary
      COG5064
      Location:25 → 455
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:67 → 93
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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