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    IL6 interleukin 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705819, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL6provided by VGNC
    Official Full Name
    interleukin 6provided by VGNC
    Primary source
    VGNC:VGNC:73732
    Locus tag
    EGK_13861
    See related
    Ensembl:ENSMMUG00000019983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IL6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (92381581..92386259, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (85553905..85559671, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676966 Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene uncharacterized LOC114676967 Neighboring gene uncharacterized LOC106997496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey. Guo G, et al. J Cell Mol Med, 2018 Sep. PMID 29992739, Free PMC Article
    2. Comparative sequence analysis of cytokine genes from human and nonhuman primates. Villinger F, et al. J Immunol, 1995 Oct 15. PMID 7561102
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkeys.
      Title: Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-6 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 17 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-6
    Names
    IL-6
    interleukin 6 (interferon, beta 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042733.2 → NP_001036198.2  interleukin-6 precursor

      See identical proteins and their annotated locations for NP_001036198.2

      Status: VALIDATED

      Source sequence(s)
      QNVO02000313
      UniProtKB/Swiss-Prot
      P51494
      UniProtKB/TrEMBL
      A0A1D5QRZ4
      Related
      ENSMMUP00000050822.2, ENSMMUT00000068705.2
      Conserved Domains (1) summary
      pfam00489
      Location:28 → 211
      IL6; Interleukin-6/G-CSF/MGF family

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      92381581..92386259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133871.2 → XP_014989357.1  interleukin-6 isoform X1

      UniProtKB/TrEMBL
      G7MLP6
      Conserved Domains (1) summary
      cl02473
      Location:82 → 212
      IL6; Interleukin-6/G-CSF/MGF family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51494.1 GenPept UniProtKB/Swiss-Prot:P51494

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials