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    UROS uroporphyrinogen III synthase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696043, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UROSprovided by VGNC
    Official Full Name
    uroporphyrinogen III synthaseprovided by VGNC
    Primary source
    VGNC:VGNC:78731
    See related
    Ensembl:ENSMMUG00000008539
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See UROS in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (126212039..126262054, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (121793670..121843210, complement)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107000307 Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene matrix metallopeptidase 21 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in uroporphyrinogen III biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase
    Names
    uroporphyrinogen III synthase (congenital erythropoietic porphyria)
    NP_001253711.1
    XP_015003909.1
    XP_015003910.1
    XP_015003911.1
    XP_015003912.1
    XP_015003913.1
    XP_015003914.1
    XP_015003917.1
    XP_028709120.1
    XP_028709121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266782.1 → NP_001253711.1  uroporphyrinogen-III synthase

      See identical proteins and their annotated locations for NP_001253711.1

      Status: PROVISIONAL

      Source sequence(s)
      JV048155
      UniProtKB/TrEMBL
      F6WBT0, G7N1D1, H9FZC1
      Related
      ENSMMUP00000068986.1, ENSMMUT00000079295.1
      Conserved Domains (1) summary
      cd06578
      Location:3 → 255
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      126212039..126262054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015148425.2 → XP_015003911.1  uroporphyrinogen-III synthase isoform X1

      UniProtKB/TrEMBL
      F7ERY4
      Conserved Domains (1) summary
      cd06578
      Location:19 → 239
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    2. XM_015148428.2 → XP_015003914.1  uroporphyrinogen-III synthase isoform X4

      Conserved Domains (1) summary
      cd06578
      Location:19 → 212
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    3. XM_015148427.2 → XP_015003913.1  uroporphyrinogen-III synthase isoform X3

      Conserved Domains (1) summary
      cd06578
      Location:3 → 223
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    4. XM_015148426.2 → XP_015003912.1  uroporphyrinogen-III synthase isoform X2

      Conserved Domains (1) summary
      cd06578
      Location:19 → 239
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    5. XM_015148424.2 → XP_015003910.1  uroporphyrinogen-III synthase isoform X1

      UniProtKB/TrEMBL
      F7ERY4
      Related
      ENSMMUP00000035543.2, ENSMMUT00000042535.3
      Conserved Domains (1) summary
      cd06578
      Location:19 → 239
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    6. XM_015148423.2 → XP_015003909.1  uroporphyrinogen-III synthase isoform X1

      UniProtKB/TrEMBL
      F7ERY4
      Related
      ENSMMUP00000080205.1, ENSMMUT00000109863.1
      Conserved Domains (1) summary
      cd06578
      Location:19 → 239
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    7. XM_028853288.1 → XP_028709121.1  uroporphyrinogen-III synthase isoform X7

      UniProtKB/TrEMBL
      G7N1D1
      Conserved Domains (1) summary
      cd06578
      Location:3 → 228
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    8. XM_028853287.1 → XP_028709120.1  uroporphyrinogen-III synthase isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZVD6
      Related
      ENSMMUP00000011199.4, ENSMMUT00000011940.4
      Conserved Domains (1) summary
      cd06578
      Location:3 → 220
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    9. XM_015148431.2 → XP_015003917.1  uroporphyrinogen-III synthase isoform X5

      UniProtKB/TrEMBL
      G7N1D1
      Conserved Domains (1) summary
      cd06578
      Location:19 → 244
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    RNA

    1. XR_003732770.1 RNA Sequence

    2. XR_003732769.1 RNA Sequence

    3. XR_001447358.2 RNA Sequence

      Related
      ENSMMUT00000093939.1

    4. XR_003732771.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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