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    UNC13B unc-13 homolog B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697393, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UNC13Bprovided by VGNC
    Official Full Name
    unc-13 homolog Bprovided by VGNC
    Primary source
    VGNC:VGNC:107120
    See related
    Ensembl:ENSMMUG00000016308
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See UNC13B in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (48841629..49077025, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (48899942..49136272, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 2B Neighboring gene RUN and SH3 domain containing 2 Neighboring gene phospholipid-transporting ATPase FetA Neighboring gene uncharacterized LOC106993706 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3 pseudogene Neighboring gene atos homolog B Neighboring gene stomatin like 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule priming IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle maturation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein unc-13 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      48841629..49077025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117500.2 → XP_014972986.1  protein unc-13 homolog B isoform X9

      UniProtKB/TrEMBL
      A0A5K1U028
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1458 → 1577
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1022
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1265 → 1401
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    2. XM_015117503.2 → XP_014972989.1  protein unc-13 homolog B isoform X11

      UniProtKB/TrEMBL
      H9FNR8
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1438 → 1557
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1021
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1264 → 1400
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    3. XM_015117499.2 → XP_014972985.1  protein unc-13 homolog B isoform X12

      UniProtKB/TrEMBL
      A0A5K1U028
      Conserved Domains (6) summary
      cd04027
      Location:602 → 728
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1459 → 1578
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:480 → 529
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:920 → 1023
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1266 → 1402
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    4. XM_015117498.2 → XP_014972984.1  protein unc-13 homolog B isoform X8

      UniProtKB/TrEMBL
      A0A5K1U028
      Conserved Domains (6) summary
      cd04027
      Location:602 → 728
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1460 → 1579
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:480 → 529
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:920 → 1024
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1267 → 1403
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    5. XM_015117502.2 → XP_014972988.1  protein unc-13 homolog B isoform X10

      UniProtKB/TrEMBL
      H9FNR8
      Related
      ENSMMUP00000019712.4, ENSMMUT00000021082.4
      Conserved Domains (6) summary
      cd04027
      Location:600 → 726
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1439 → 1558
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:478 → 527
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:918 → 1022
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1265 → 1401
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    6. XM_015117495.2 → XP_014972981.1  protein unc-13 homolog B isoform X5

      UniProtKB/TrEMBL
      A0A1D5QDA2
      Conserved Domains (5) summary
      cd04027
      Location:982 → 1108
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1839 → 1958
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:860 → 909
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1300 → 1403
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1646 → 1782
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    7. XM_015117494.2 → XP_014972980.1  protein unc-13 homolog B isoform X4

      UniProtKB/TrEMBL
      A0A1D5QDA2
      Conserved Domains (5) summary
      cd04027
      Location:982 → 1108
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1840 → 1959
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:860 → 909
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1300 → 1404
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1647 → 1783
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    8. XM_015117497.2 → XP_014972983.1  protein unc-13 homolog B isoform X7

      UniProtKB/TrEMBL
      A0A1D5QDA2
      Related
      ENSMMUP00000046021.2, ENSMMUT00000066953.2
      Conserved Domains (5) summary
      cd04027
      Location:982 → 1108
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1821 → 1940
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:860 → 909
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1300 → 1404
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1647 → 1783
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    9. XM_015117496.2 → XP_014972982.1  protein unc-13 homolog B isoform X6

      UniProtKB/TrEMBL
      A0A1D5QDA2
      Conserved Domains (5) summary
      cd04027
      Location:980 → 1106
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:1838 → 1957
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:858 → 907
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1298 → 1402
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1645 → 1781
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    10. XM_015117493.2 → XP_014972979.2  protein unc-13 homolog B isoform X1

      Conserved Domains (1) summary
      cd08394
      Location:1 → 127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

    11. XM_028835082.1 → XP_028690915.1  protein unc-13 homolog B isoform X3

    12. XM_028835081.1 → XP_028690914.1  protein unc-13 homolog B isoform X2

      Conserved Domains (1) summary
      cl14603
      Location:1 → 78
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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