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    C5 complement C5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700467, updated on 17-Aug-2024

    Summary

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    Official Symbol
    C5provided by VGNC
    Official Full Name
    complement C5provided by VGNC
    Primary source
    VGNC:VGNC:70475
    See related
    Ensembl:ENSMMUG00000020124
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (21656653..21755723)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (18218040..18317077)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene RAB14, member RAS oncogene family Neighboring gene centriolin Neighboring gene actin-related protein 2/3 complex subunit 3 pseudogene Neighboring gene TNF receptor associated factor 1 Neighboring gene PHD finger protein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      21656653..21755723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015116942.2 → XP_014972428.2  complement C5 isoform X3

      Conserved Domains (7) summary
      cd00017
      Location:682 → 750
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam00207
      Location:772 → 856
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:126 → 219
      A2M_N; MG2 domain
      pfam07703
      Location:467 → 610
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:354 → 457
      MG4; Macroglobulin domain MG4
      pfam17790
      Location:20 → 120
      MG1; Macroglobulin domain MG1
      pfam17791
      Location:221 → 301
      MG3; Macroglobulin domain MG3

    2. XM_015116941.2 → XP_014972427.2  complement C5 isoform X1

      UniProtKB/TrEMBL
      F7GHV1, G7NG17
      Related
      ENSMMUP00000026497.4, ENSMMUT00000028315.4
      Conserved Domains (10) summary
      cd00017
      Location:682 → 750
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:995 → 1300
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03582
      Location:1527 → 1676
      NTR_complement_C5; NTR/C345C domain, complement C5 subfamily; The NTR domain found in complement C5 is also known as C345C because it occurs at the C-terminus of complement C3, C4 and C5. Complement C5 is activated by C5 convertase, which itself is a complex between C3b ...
      pfam00207
      Location:772 → 859
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:126 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1421 → 1509
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:467 → 610
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:354 → 457
      MG4; Macroglobulin domain MG4
      pfam17790
      Location:20 → 120
      MG1; Macroglobulin domain MG1
      pfam17791
      Location:221 → 301
      MG3; Macroglobulin domain MG3

    3. XM_028834901.1 → XP_028690734.1  complement C5 isoform X2

      UniProtKB/TrEMBL
      G7NG17
      Conserved Domains (8) summary
      COG2373
      Location:67 → 624
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd00017
      Location:682 → 750
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:852 → 1157
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03582
      Location:1384 → 1533
      NTR_complement_C5; NTR/C345C domain, complement C5 subfamily; The NTR domain found in complement C5 is also known as C345C because it occurs at the C-terminus of complement C3, C4 and C5. Complement C5 is activated by C5 convertase, which itself is a complex between C3b ...
      pfam01835
      Location:126 → 219
      A2M_N; MG2 domain
      pfam00207
      Location:772 → 820
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1278 → 1366
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:467 → 610
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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