GPX2 glutathione peroxidase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: GPX2provided by VGNC
Official Full Name: glutathione peroxidase 2provided by VGNC
Primary source: VGNC:VGNC:73152
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (127002037..127005787, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (126887825..126891573, complement)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutathione peroxidase 2

Names: glutathione peroxidase 2 (gastrointestinal)

NP_001108609.2

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115137.2 → NP_001108609.2 glutathione peroxidase 2

Status: REVIEWED

Source sequence(s)

CO774353, JV649196, QNVO02000421

UniProtKB/TrEMBL

A0A1D5R361

Conserved Domains (1) summary

cd00340
Location:7 → 182

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...