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    OPRK1 opioid receptor kappa 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710783, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OPRK1provided by VGNC
    Official Full Name
    opioid receptor kappa 1provided by VGNC
    Primary source
    VGNC:VGNC:104467
    See related
    Ensembl:ENSMMUG00000065247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Summary
    This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See OPRK1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (53869933..53895542, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (48242898..48268504)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2 pseudogene Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene mitogen-activated protein kinase 6 pseudogene Neighboring gene ATPase H+ transporting V1 subunit H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
    2. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dynorphin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kappa-type opioid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321097.2 → NP_001308026.2  kappa-type opioid receptor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon , while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      QNVO02000453
      UniProtKB/TrEMBL
      A0A5F7ZV88, F7H1J2
      Related
      ENSMMUP00000069541.1, ENSMMUT00000084451.1
      Conserved Domains (1) summary
      cd15091
      Location:60 → 341
      7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001321098.2 → NP_001308027.2  kappa-type opioid receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      QNVO02000453
      UniProtKB/TrEMBL
      F7H1J2
      Conserved Domains (1) summary
      cd15091
      Location:60 → 341
      7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      53869933..53895542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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