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    OTOF otoferlin [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696717, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OTOFprovided by VGNC
    Official Full Name
    otoferlinprovided by VGNC
    Primary source
    VGNC:VGNC:75724
    See related
    Ensembl:ENSMMUG00000014292
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See OTOF in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (82417671..82520498)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (26723411..26826586, complement)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114671752 Neighboring gene ciliary microtubule inner protein 2C Neighboring gene dynein regulatory complex subunit 1 Neighboring gene selenoprotein I Neighboring gene adhesion G protein-coupled receptor F3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    otoferlin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      82417671..82520498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111892.2 → XP_014967378.2  otoferlin isoform X1

      UniProtKB/TrEMBL
      F7BSS7, G7N9L3
      Related
      ENSMMUP00000018772.4, ENSMMUT00000020056.4
      Conserved Domains (10) summary
      cd04011
      Location:251 → 362
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:960 → 1097
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:418 → 567
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1492 → 1615
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 130
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1732 → 1865
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      COG5038
      Location:1330 → 1596
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      pfam16165
      Location:1875 → 1993
      Ferlin_C; Ferlin C-terminus
      pfam08150
      Location:843 → 917
      FerB; FerB (NUC096) domain
      pfam08151
      Location:360 → 410
      FerI; FerI (NUC094) domain

    2. XM_015111893.2 → XP_014967379.2  otoferlin isoform X2

      UniProtKB/TrEMBL
      G7N9L3
      Conserved Domains (10) summary
      cd04011
      Location:251 → 362
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:960 → 1097
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:418 → 567
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1492 → 1615
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 130
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1732 → 1865
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      COG5038
      Location:1330 → 1596
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      pfam16165
      Location:1875 → 1993
      Ferlin_C; Ferlin C-terminus
      pfam08150
      Location:843 → 917
      FerB; FerB (NUC096) domain
      pfam08151
      Location:360 → 410
      FerI; FerI (NUC094) domain

    3. XM_028831868.1 → XP_028687701.1  otoferlin isoform X5

      UniProtKB/TrEMBL
      G7N9L3
      Conserved Domains (10) summary
      cd04011
      Location:266 → 377
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:975 → 1112
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:433 → 582
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1487 → 1610
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 130
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1727 → 1860
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      COG5038
      Location:1325 → 1591
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      pfam16165
      Location:1870 → 1988
      Ferlin_C; Ferlin C-terminus
      pfam08150
      Location:858 → 932
      FerB; FerB (NUC096) domain
      pfam08151
      Location:375 → 425
      FerI; FerI (NUC094) domain

    4. XM_015111894.2 → XP_014967380.2  otoferlin isoform X4

      UniProtKB/TrEMBL
      G7N9L3
      Conserved Domains (10) summary
      cd04011
      Location:251 → 362
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:960 → 1097
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:418 → 567
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1472 → 1595
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 130
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1712 → 1845
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      COG5038
      Location:1310 → 1576
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      pfam16165
      Location:1855 → 1973
      Ferlin_C; Ferlin C-terminus
      pfam08150
      Location:843 → 917
      FerB; FerB (NUC096) domain
      pfam08151
      Location:360 → 410
      FerI; FerI (NUC094) domain

    5. XM_028831867.1 → XP_028687700.1  otoferlin isoform X3

      UniProtKB/TrEMBL
      G7N9L3
      Conserved Domains (10) summary
      cd04011
      Location:251 → 362
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:960 → 1097
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:418 → 567
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1472 → 1595
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 130
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1712 → 1845
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      COG5038
      Location:1310 → 1576
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      pfam16165
      Location:1855 → 1973
      Ferlin_C; Ferlin C-terminus
      pfam08150
      Location:843 → 917
      FerB; FerB (NUC096) domain
      pfam08151
      Location:360 → 410
      FerI; FerI (NUC094) domain
    Nucleotide Protein
    Heading Accession and Version

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