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    TEK TEK receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707455, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TEKprovided by VGNC
    Official Full Name
    TEK receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:78308
    Locus tag
    EGK_07642
    See related
    Ensembl:ENSMMUG00000006080
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TEK in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (56522803..56644903, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (56644645..56766779, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 3B Neighboring gene interferon kappa Neighboring gene equatorin Neighboring gene intraflagellar transport 74 Neighboring gene uncharacterized LOC114672776 Neighboring gene leucine rich repeat containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    angiopoietin-1 receptor
    Names
    Angiopoietin-1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      56522803..56644903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117580.2 → XP_014973066.2  angiopoietin-1 receptor isoform X2

      Conserved Domains (5) summary
      cd05088
      Location:815 → 1117
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00055
      Location:230 → 275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:639 → 731
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10430
      Location:24 → 118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
      pfam00041
      Location:544 → 625
      fn3; Fibronectin type III domain

    2. XM_001105270.4 → XP_001105270.2  angiopoietin-1 receptor isoform X1

      UniProtKB/TrEMBL
      F6VW12
      Related
      ENSMMUP00000007986.4, ENSMMUT00000008498.4
      Conserved Domains (5) summary
      cd05088
      Location:816 → 1118
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00055
      Location:230 → 275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:639 → 731
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10430
      Location:24 → 118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
      pfam00041
      Location:544 → 625
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version

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