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    SPAST spastin [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706264, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SPASTprovided by VGNC
    Official Full Name
    spastinprovided by VGNC
    Primary source
    VGNC:VGNC:77857
    See related
    Ensembl:ENSMMUG00000021691
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SPAST in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (76740289..76831153, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (32558477..32651160)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ATP-dependent RNA helicase DDX50 pseudogene Neighboring gene solute carrier family 30 member 6 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene mediator of cell motility 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spastin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      76740289..76831153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028831798.1 → XP_028687631.1  spastin isoform X4

      UniProtKB/TrEMBL
      A0A5F8AFG0
      Conserved Domains (4) summary
      cd02679
      Location:114 → 192
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam09336
      Location:545 → 577
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:498 → 552
      AAA_lid_3; AAA+ lid domain
      cd19524
      Location:308 → 471
      RecA-like_spastin; ATPase domain of spastin

    2. XM_015112061.2 → XP_014967547.1  spastin isoform X2

      UniProtKB/TrEMBL
      A0A5F8AFG0
      Conserved Domains (5) summary
      smart00382
      Location:371 → 507
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114 → 192
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:375 → 505
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:577 → 609
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:338 → 394
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_015112063.2 → XP_014967549.1  spastin isoform X3

      UniProtKB/TrEMBL
      A0A5F8AFG0, H9FYV5
      Related
      ENSMMUP00000070411.1, ENSMMUT00000081348.1
      Conserved Domains (5) summary
      smart00382
      Location:340 → 476
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114 → 193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:344 → 474
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:546 → 578
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:307 → 363
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_028831799.1 → XP_028687632.1  spastin isoform X5

      UniProtKB/TrEMBL
      A0A5F8A464, A0A5F8AHS4
      Related
      ENSMMUP00000071714.1, ENSMMUT00000101057.1
      Conserved Domains (3) summary
      cd02679
      Location:114 → 193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam17862
      Location:531 → 566
      AAA_lid_3; AAA+ lid domain
      cd19524
      Location:341 → 504
      RecA-like_spastin; ATPase domain of spastin

    5. XM_015112060.2 → XP_014967546.1  spastin isoform X1

      UniProtKB/TrEMBL
      A0A5F8AFG0, F7F0D1, H9FYV4
      Related
      ENSMMUP00000028561.3, ENSMMUT00000030520.4
      Conserved Domains (5) summary
      smart00382
      Location:372 → 508
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114 → 193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:376 → 506
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:578 → 610
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:339 → 395
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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