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    NLRP3 NLR family pyrin domain containing 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701278, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NLRP3provided by VGNC
    Official Full Name
    NLR family pyrin domain containing 3provided by VGNC
    Primary source
    VGNC:VGNC:75186
    See related
    Ensembl:ENSMMUG00000005946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NLRP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (1562863..1596246, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (224047255..224080212)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678510 Neighboring gene uncharacterized LOC114678532 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 pseudogene Neighboring gene olfactory receptor 2B11 Neighboring gene uncharacterized LOC106995270 Neighboring gene zinc finger protein 496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of oocyte-selective NLRP genes in rhesus macaque monkeys (Macaca mulatta). McDaniel P, et al. Mol Reprod Dev, 2009 Feb. PMID 18509866
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NLRP3 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114351.1 → NP_001107823.1  NACHT, LRR and PYD domains-containing protein 3

      See identical proteins and their annotated locations for NP_001107823.1

      Status: PROVISIONAL

      Source sequence(s)
      EU344966
      UniProtKB/Swiss-Prot
      B0FPE9
      UniProtKB/TrEMBL
      G7MFJ4
      Related
      ENSMMUP00000053959.2, ENSMMUT00000074048.2
      Conserved Domains (7) summary
      smart00368
      Location:967 → 994
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:575 → 950
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:742 → 770
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:220 → 389
      NACHT; NACHT domain
      pfam14484
      Location:144 → 210
      FISNA; Fish-specific NACHT associated domain
      pfam17779
      Location:466 → 520
      NOD2_WH; NOD2 winged helix domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      1562863..1596246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015127781.2 → XP_014983267.2  NACHT, LRR and PYD domains-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R0X5, G1K370, G7MFJ4
      Related
      ENSMMUP00000007829.4, ENSMMUT00000008331.4
      Conserved Domains (6) summary
      smart00368
      Location:967 → 994
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:575 → 950
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:742 → 770
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:220 → 389
      NACHT; NACHT domain
      pfam14484
      Location:144 → 209
      FISNA; Fish-specific NACHT associated domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0FPE9.1 GenPept UniProtKB/Swiss-Prot:B0FPE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials