CD58 CD58 molecule [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CD58provided by VGNC
Official Full Name: CD58 moleculeprovided by VGNC
Primary source: VGNC:VGNC:70772
See related: Ensembl:ENSMMUG00000008156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	1	NC_041754.1 (107688607..107745040)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	1	NC_027893.1 (117587314..117643832, complement)

Chromosome 1 - NC_041754.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFalpha production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
Title: Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lymphocyte function-associated antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267785.1 → NP_001254714.1 lymphocyte function-associated antigen 3

See identical proteins and their annotated locations for NP_001254714.1

Status: PROVISIONAL

Source sequence(s)

JU477964

UniProtKB/TrEMBL

F7HE75, H9G2A1

Related

ENSMMUP00000010678.4, ENSMMUT00000011394.4

Conserved Domains (1) summary

cd05741
Location:39 → 120

Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041754.1 Reference Mmul_10 Primary Assembly

Range

107688607..107745040

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015147245.2 → XP_015002731.2 lymphocyte function-associated antigen 3 isoform X1

UniProtKB/TrEMBL

A0A5F8A1P2

Related

ENSMMUP00000070847.1, ENSMMUT00000103653.1

Conserved Domains (1) summary

cd05775
Location:35 → 121

Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains