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    OPTN optineurin [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574252, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OPTNprovided by VGNC
    Official Full Name
    optineurinprovided by VGNC
    Primary source
    VGNC:VGNC:75415
    See related
    Ensembl:ENSMMUG00000005601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See OPTN in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (14253526..14305816)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (13181621..13228891)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107000046 Neighboring gene coiled-coil domain containing 3 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene upper zone of growth plate and cartilage matrix associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression profiling of optineurin in the rhesus monkey. Rezaie T, et al. Invest Ophthalmol Vis Sci, 2005 Jul. PMID 15980228
    2. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Rezaie T, et al. Science, 2002 Feb 8. PMID 11834836
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    optineurin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032897.1 → NP_001028069.1  optineurin

      See identical proteins and their annotated locations for NP_001028069.1

      Status: PROVISIONAL

      Source sequence(s)
      AY228374
      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Related
      ENSMMUP00000007407.4, ENSMMUT00000007881.4
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      14253526..14305816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028853221.1 → XP_028709054.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Related
      ENSMMUP00000067667.1, ENSMMUT00000102245.1
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    2. XM_028853223.1 → XP_028709056.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    3. XM_028853222.1 → XP_028709055.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Related
      ENSMMUP00000036259.3, ENSMMUT00000043250.3
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    4. XM_028853220.1 → XP_028709053.1  optineurin isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZL36, G7N1L3
      Related
      ENSMMUP00000065325.1, ENSMMUT00000100614.1
      Conserved Domains (4) summary
      COG1196
      Location:100 → 438
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:59 → 125
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:567 → 592
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:424 → 523
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    5. XM_028853224.1 → XP_028709057.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    6. XM_015146463.2 → XP_015001949.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Related
      ENSMMUP00000079351.1, ENSMMUT00000092013.1
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    7. XM_015146465.2 → XP_015001951.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    8. XM_028853219.1 → XP_028709052.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Related
      ENSMMUP00000071942.1, ENSMMUT00000109882.1
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    9. XM_015146462.2 → XP_015001948.1  optineurin isoform X1

      UniProtKB/Swiss-Prot
      Q861Q8
      UniProtKB/TrEMBL
      G7N1L3, H9FNG7
      Conserved Domains (4) summary
      COG1196
      Location:199 → 477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11577
      Location:37 → 103
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:545 → 570
      zf_C2H2_10; C2H2 type zinc-finger
      pfam16516
      Location:402 → 501
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q861Q8.1 GenPept UniProtKB/Swiss-Prot:Q861Q8

    Gene LinkOut

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