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    SETDB2 SET domain bifurcated histone lysine methyltransferase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706277, updated on 14-Nov-2024

    Summary

    Official Symbol
    SETDB2provided by VGNC
    Official Full Name
    SET domain bifurcated histone lysine methyltransferase 2provided by VGNC
    Primary source
    VGNC:VGNC:77282
    Locus tag
    EGK_09322
    See related
    Ensembl:ENSMMUG00000013473
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See SETDB2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 17 NC_041770.1 (27904863..27959238)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 17 NC_027909.1 (28693408..28748198)

    Chromosome 17 - NC_041770.1Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39 like Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene U6 spliceosomal RNA Neighboring gene PHD finger protein 11 Neighboring gene RCC1 and BTB domain containing protein 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin organization IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SETDB2
    Names
    SET domain bifurcated 2
    XP_014976542.1
    XP_014976543.1
    XP_014976544.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041770.1 Reference Mmul_10 Primary Assembly

      Range
      27904863..27959238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015121057.2XP_014976543.1  histone-lysine N-methyltransferase SETDB2 isoform X1

      UniProtKB/TrEMBL
      A0A663D982, A0A8J8XZY7, F6ZLU9, G7NK50, H9YUM8
      Related
      ENSMMUP00000017711.3, ENSMMUT00000018910.4
      Conserved Domains (3) summary
      smart00317
      Location:630696
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd01395
      Location:164224
      HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
      pfam05033
      Location:246359
      Pre-SET; Pre-SET motif
    2. XM_015121056.2XP_014976542.1  histone-lysine N-methyltransferase SETDB2 isoform X1

      UniProtKB/TrEMBL
      A0A663D982, A0A8J8XZY7, F6ZLU9, G7NK50, H9YUM8
      Conserved Domains (3) summary
      smart00317
      Location:630696
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd01395
      Location:164224
      HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
      pfam05033
      Location:246359
      Pre-SET; Pre-SET motif
    3. XM_015121058.2XP_014976544.1  histone-lysine N-methyltransferase SETDB2 isoform X2

      UniProtKB/TrEMBL
      H9YUM8
      Conserved Domains (3) summary
      smart00317
      Location:589655
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:205318
      Pre-SET; Pre-SET motif
      cl00110
      Location:164188
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...