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    ARHGAP22 Rho GTPase activating protein 22 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710956, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGAP22provided by VGNC
    Official Full Name
    Rho GTPase activating protein 22provided by VGNC
    Primary source
    VGNC:VGNC:69931
    See related
    Ensembl:ENSMMUG00000004063
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGAP22 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (48713115..48923163)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (42550879..42760814, complement)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene uncharacterized LOC107000120 Neighboring gene 60S ribosomal protein L13a pseudogene Neighboring gene uncharacterized LOC114669946 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene uncharacterized LOC107000119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      48713115..48923163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028826344.1 → XP_028682177.1  rho GTPase-activating protein 22 isoform X7

      Conserved Domains (2) summary
      cl02570
      Location:114 → 210
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17171
      Location:42 → 127
      PH-like; Pleckstrin homology-like domain

    2. XM_015146986.2 → XP_015002472.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QK46, F7E581
      Related
      ENSMMUP00000048419.2, ENSMMUT00000073726.2
      Conserved Domains (4) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44 → 150
      PH; PH domain
      cl03075
      Location:572 → 684
      GrpE; nucleotide exchange factor GrpE

    3. XM_001108566.4 → XP_001108566.1  rho GTPase-activating protein 22 isoform X3

      UniProtKB/TrEMBL
      F7E581
      Related
      ENSMMUP00000035932.3, ENSMMUT00000042922.3
      Conserved Domains (4) summary
      cd04390
      Location:157 → 355
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44 → 150
      PH; PH domain
      cl03075
      Location:556 → 668
      GrpE; nucleotide exchange factor GrpE

    4. XM_002805637.3 → XP_002805683.1  rho GTPase-activating protein 22 isoform X2

      UniProtKB/TrEMBL
      F6ZKA6, F7E581
      Related
      ENSMMUP00000005432.4, ENSMMUT00000005769.4
      Conserved Domains (4) summary
      cd04390
      Location:167 → 365
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36 → 151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:38 → 144
      PH; PH domain
      cl03075
      Location:566 → 678
      GrpE; nucleotide exchange factor GrpE

    5. XM_028826341.1 → XP_028682174.1  rho GTPase-activating protein 22 isoform X5

      UniProtKB/TrEMBL
      F7E581
      Conserved Domains (3) summary
      COG1196
      Location:546 → 634
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd04390
      Location:108 → 306
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cl17171
      Location:36 → 121
      PH-like; Pleckstrin homology-like domain

    6. XM_001108619.4 → XP_001108619.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      F7E581
      Conserved Domains (4) summary
      cd04390
      Location:151 → 349
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36 → 151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:38 → 144
      PH; PH domain
      cl03075
      Location:550 → 662
      GrpE; nucleotide exchange factor GrpE

    7. XM_028826342.1 → XP_028682175.1  rho GTPase-activating protein 22 isoform X6

      UniProtKB/TrEMBL
      F7E569
      Related
      ENSMMUP00000035933.2, ENSMMUT00000042923.3
      Conserved Domains (3) summary
      COG1196
      Location:515 → 603
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd04390
      Location:77 → 275
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_003719310.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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