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    EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714475, updated on 17-Aug-2024

    Summary

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    Official Symbol
    EDEM3provided by VGNC
    Official Full Name
    ER degradation enhancing alpha-mannosidase like protein 3provided by VGNC
    Primary source
    VGNC:VGNC:72055
    Locus tag
    EGK_01856
    See related
    Ensembl:ENSMMUG00000005410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See EDEM3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (41950525..42019549, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (182493605..182563652)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene chromosome 1 C1orf21 homolog Neighboring gene tRNA (uracil(54)-C(5))-methyltransferase homolog Neighboring gene uncharacterized LOC114679528 Neighboring gene riboflavin kinase pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene niban apoptosis regulator 1 Neighboring gene uncharacterized LOC114679529

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endoplasmic reticulum mannose trimming IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ER degradation-enhancing alpha-mannosidase-like protein 3
    Names
    ER degradation-enhancing alpha-mannosidase-like 3
    NP_001253723.1
    XP_014976889.1
    XP_014976896.1
    XP_014976906.1
    XP_014976909.1
    XP_014976914.1
    XP_014976920.1
    XP_028700948.1
    XP_028700955.1
    XP_028700960.1
    XP_028700969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266794.1 → NP_001253723.1  ER degradation-enhancing alpha-mannosidase-like protein 3

      See identical proteins and their annotated locations for NP_001253723.1

      Status: PROVISIONAL

      Source sequence(s)
      JU472426
      UniProtKB/TrEMBL
      A0A1D5QU54, A0A5S6R972, A0A8J8YRU0, G7MF29
      Related
      ENSMMUP00000061577.1, ENSMMUT00000102460.1
      Conserved Domains (3) summary
      cd02126
      Location:664 → 789
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47
      NF033609
      Location:790 → 901
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      41950525..42019549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845127.1 → XP_028700960.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X9

      Conserved Domains (3) summary
      PRK08581
      Location:790 → 906
      PRK08581; amidase domain-containing protein
      cd02126
      Location:645 → 770
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. XM_028845122.1 → XP_028700955.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X8

      Conserved Domains (3) summary
      PRK08581
      Location:790 → 917
      PRK08581; amidase domain-containing protein
      cd02126
      Location:645 → 770
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    3. XM_015121410.2 → XP_014976896.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2

      UniProtKB/TrEMBL
      F7GT33
      Related
      ENSMMUP00000007148.4, ENSMMUT00000007610.4
      Conserved Domains (3) summary
      PRK08581
      Location:809 → 936
      PRK08581; amidase domain-containing protein
      cd02126
      Location:664 → 789
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    4. XM_028845136.1 → XP_028700969.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X10

      Conserved Domains (3) summary
      cd02126
      Location:646 → 771
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47
      NF033609
      Location:772 → 883
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    5. XM_028845115.1 → XP_028700948.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X7

      Conserved Domains (3) summary
      PRK08581
      Location:791 → 918
      PRK08581; amidase domain-containing protein
      cd02126
      Location:646 → 771
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    6. XM_015121434.2 → XP_014976920.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X6

      Conserved Domains (3) summary
      cd02126
      Location:665 → 790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47
      NF033609
      Location:791 → 902
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    7. XM_015121428.2 → XP_014976914.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X5

      Conserved Domains (3) summary
      PRK08581
      Location:809 → 925
      PRK08581; amidase domain-containing protein
      cd02126
      Location:665 → 790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    8. XM_015121420.2 → XP_014976906.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X3

      Conserved Domains (3) summary
      PRK08581
      Location:809 → 936
      PRK08581; amidase domain-containing protein
      cd02126
      Location:665 → 790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    9. XM_015121423.2 → XP_014976909.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X4

      Conserved Domains (3) summary
      PRK08581
      Location:810 → 926
      PRK08581; amidase domain-containing protein
      cd02126
      Location:665 → 790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47

    10. XM_015121403.2 → XP_014976889.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1

      Conserved Domains (3) summary
      PRK08581
      Location:810 → 937
      PRK08581; amidase domain-containing protein
      cd02126
      Location:665 → 790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:59 → 498
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version

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