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    MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717866, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAP3K3provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:81462
    See related
    Ensembl:ENSMMUG00000016751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MAP3K3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (60072729..60147828)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (57229656..57304903)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene protein FAM136A pseudogene Neighboring gene LIM domain containing 2 Neighboring gene STE20 related adaptor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 3
    NP_001244715.1
    XP_014975537.1
    XP_014975538.1
    XP_014975539.1
    XP_014975540.2
    XP_028691593.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257786.1 → NP_001244715.1  mitogen-activated protein kinase kinase kinase 3

      See identical proteins and their annotated locations for NP_001244715.1

      Status: PROVISIONAL

      Source sequence(s)
      JU334556
      UniProtKB/TrEMBL
      A0A1D5QJ66, F7AIB6
      Related
      ENSMMUP00000048089.1, ENSMMUT00000075594.2
      Conserved Domains (2) summary
      cd06405
      Location:76 → 154
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:392 → 652
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      60072729..60147828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015120053.2 → XP_014975539.1  mitogen-activated protein kinase kinase kinase 3 isoform X4

      UniProtKB/TrEMBL
      F7AIB6
      Conserved Domains (2) summary
      cd06405
      Location:45 → 123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:357 → 617
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    2. XM_015120051.2 → XP_014975537.1  mitogen-activated protein kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      F7AIB6, I0FRT5
      Conserved Domains (2) summary
      cd06405
      Location:76 → 154
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:388 → 648
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    3. XM_015120052.2 → XP_014975538.1  mitogen-activated protein kinase kinase kinase 3 isoform X3

      UniProtKB/TrEMBL
      F7AIB6, H9FUJ9
      Conserved Domains (2) summary
      cd06405
      Location:45 → 123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:361 → 621
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    4. XM_028835760.1 → XP_028691593.1  mitogen-activated protein kinase kinase kinase 3 isoform X2

      UniProtKB/TrEMBL
      F7AIB6
      Related
      ENSMMUP00000022022.4, ENSMMUT00000023539.4
      Conserved Domains (2) summary
      cd06405
      Location:66 → 144
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:382 → 642
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    5. XM_015120054.2 → XP_014975540.2  mitogen-activated protein kinase kinase kinase 3 isoform X5

      UniProtKB/TrEMBL
      F7AIB6
      Conserved Domains (2) summary
      cd06405
      Location:21 → 99
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:337 → 597
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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