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    MAP2K5 mitogen-activated protein kinase kinase 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711672, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAP2K5provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase 5provided by VGNC
    Primary source
    VGNC:VGNC:81455
    See related
    Ensembl:ENSMMUG00000014482
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MAP2K5 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (44198001..44456107)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (44382700..44642478)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC106999224 Neighboring gene chromosome 7 C15orf61 homolog Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene U6 spliceosomal RNA Neighboring gene SKI family transcriptional corepressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 5
    XP_014998032.1
    XP_014998033.1
    XP_014998034.1
    XP_028706901.1
    XP_028706902.1
    XP_028706903.1
    XP_028706904.1
    XP_028706905.1
    XP_028706906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      44198001..44456107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142547.2 → XP_014998033.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

      UniProtKB/TrEMBL
      A0A1D5Q0Z4, A0A1D5QDK2
      Related
      ENSMMUP00000041706.2, ENSMMUT00000070927.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 432
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    2. XM_015142546.2 → XP_014998032.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

      UniProtKB/TrEMBL
      F7GJH7, G7MXW8, H9EPL8
      Related
      ENSMMUP00000019017.4, ENSMMUT00000020318.4
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 442
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    3. XM_028851069.1 → XP_028706902.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

      UniProtKB/TrEMBL
      G7MXW8
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 430
      PKc_like; Protein Kinases, catalytic domain

    4. XM_028851068.1 → XP_028706901.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      G7MXW8
      Related
      ENSMMUP00000019016.4, ENSMMUT00000020317.4
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 457
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    5. XM_015142548.2 → XP_014998034.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QUD3
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 406
      PKc_like; Protein Kinases, catalytic domain

    6. XM_028851070.1 → XP_028706903.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

      UniProtKB/TrEMBL
      A0A1D5QDK2
      Related
      ENSMMUP00000046121.2, ENSMMUT00000074094.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 447
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    7. XM_028851071.1 → XP_028706904.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X7

      UniProtKB/TrEMBL
      A0A1D5QUD3
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 396
      PKc_like; Protein Kinases, catalytic domain

    8. XM_028851073.1 → XP_028706906.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X8

      UniProtKB/TrEMBL
      G7MXW8
      Conserved Domains (2) summary
      cd06619
      Location:87 → 380
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
      cl02720
      Location:1 → 30
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

    9. XM_028851072.1 → XP_028706905.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X8

      UniProtKB/TrEMBL
      G7MXW8
      Conserved Domains (2) summary
      cd06619
      Location:87 → 380
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
      cl02720
      Location:1 → 30
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    Nucleotide Protein
    Heading Accession and Version

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