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    SMURF1 SMAD specific E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718616, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMURF1provided by VGNC
    Official Full Name
    SMAD specific E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:77726
    See related
    Ensembl:ENSMMUG00000009183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SMURF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (41125533..41247955, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (124449745..124572085, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene transformation/transcription domain associated protein Neighboring gene E3 ubiquitin-protein ligase RNF14 pseudogene Neighboring gene uncharacterized LOC114676870 Neighboring gene karyopherin subunit alpha 7 Neighboring gene myosin heavy chain 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SMURF1
    NP_001244560.1
    XP_014989809.1
    XP_014989810.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257631.1 → NP_001244560.1  E3 ubiquitin-protein ligase SMURF1

      See identical proteins and their annotated locations for NP_001244560.1

      Status: PROVISIONAL

      Source sequence(s)
      JU335584
      UniProtKB/TrEMBL
      F7HPB0, H9FXH8
      Related
      ENSMMUP00000072089.1, ENSMMUT00000106848.1
      Conserved Domains (4) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:281 → 313
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:397 → 725
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:373 → 725
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      41125533..41247955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015134323.2 → XP_014989809.1  E3 ubiquitin-protein ligase SMURF1 isoform X1

      UniProtKB/TrEMBL
      F7HPB0, H9EPZ4
      Related
      ENSMMUP00000012038.4, ENSMMUT00000012841.4
      Conserved Domains (4) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:281 → 313
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:397 → 728
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:373 → 728
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_015134324.2 → XP_014989810.1  E3 ubiquitin-protein ligase SMURF1 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZW63, G7MNQ4
      Related
      ENSMMUP00000068857.1, ENSMMUT00000108535.1
      Conserved Domains (4) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:307 → 339
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:423 → 754
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:399 → 754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
    Heading Accession and Version

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