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    NCF2 neutrophil cytosolic factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715052, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NCF2provided by VGNC
    Official Full Name
    neutrophil cytosolic factor 2provided by VGNC
    Primary source
    VGNC:VGNC:75140
    See related
    Ensembl:ENSMMUG00000018460
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NCF2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (40822456..40858532, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (183710540..183746678)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene uncharacterized LOC114679499 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene actin related protein 2/3 complex subunit 5 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene ral guanine nucleotide dissociation stimulator like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in respiratory burst IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil cytosol factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      40822456..40858532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015122153.2 → XP_014977639.1  neutrophil cytosol factor 2 isoform X2

      UniProtKB/TrEMBL
      F7HCR8
      Conserved Domains (6) summary
      cd11871
      Location:244 → 297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      cd12046
      Location:447 → 499
      SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      sd00006
      Location:6 → 32
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:71 → 98
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:50 → 98
      TPR_11; TPR repeat
      cl02720
      Location:351 → 416
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

    2. XM_015122149.2 → XP_014977635.1  neutrophil cytosol factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5M3, F7HCR8
      Related
      ENSMMUP00000043339.1, ENSMMUT00000056439.2
      Conserved Domains (6) summary
      cd06406
      Location:351 → 429
      PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
      cd11871
      Location:244 → 297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      cd12046
      Location:461 → 513
      SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      sd00006
      Location:6 → 32
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:71 → 98
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:50 → 98
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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