U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LOC719678 neuronal acetylcholine receptor subunit alpha-4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719678, updated on 9-Nov-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC719678
    Gene description
    neuronal acetylcholine receptor subunit alpha-4
    See related
    Ensembl:ENSMMUG00000064465
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    nica4
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC719678 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 Unlocalized Scaffold NW_021160252.1 (57973..72771, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (947628..957099)

    NW_021160252.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(XX) chain-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114675482

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Fu XW, et al. Am J Respir Cell Mol Biol, 2009 Jul. PMID 19097990, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    neuronal acetylcholine receptor subunit alpha-4
    Names
    cholinergic receptor, nicotinic, alpha 4 (neuronal)
    nicotinic acetylcholine receptor subunit alpha4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NW_021160252.1 Reference Mmul_10 Primary Assembly

      Range
      57973..72771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028842716.1 → XP_028698549.1  neuronal acetylcholine receptor subunit alpha-4 isoform X1

      UniProtKB/TrEMBL
      F7AT89, F7FNA1
      Related
      ENSMMUP00000038270.3, ENSMMUT00000045248.3
      Conserved Domains (4) summary
      PHA02682
      Location:399 → 541
      PHA02682; ORF080 virion core protein; Provisional
      cd03558
      Location:161 → 175
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:37 → 243
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
      pfam02932
      Location:250 → 617
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. XM_015148617.2 → XP_015004103.1  neuronal acetylcholine receptor subunit alpha-4 isoform X2

      Conserved Domains (3) summary
      pfam02931
      Location:1 → 67
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:74 → 441
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      pfam10514
      Location:251 → 345
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    3. XM_015148618.2 → XP_015004104.1  neuronal acetylcholine receptor subunit alpha-4 isoform X2

      Conserved Domains (3) summary
      pfam02931
      Location:1 → 67
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:74 → 441
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      pfam10514
      Location:251 → 345
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials