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    MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707059, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MTHFD1provided by VGNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:84399
    See related
    Ensembl:ENSMMUG00000001319
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFD1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (126445010..126519281)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (126327117..126401947)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene estrogen receptor 2 Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    XP_014999368.1
    XP_028707442.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      126445010..126519281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143882.2 → XP_014999368.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A1D5QF17
      Related
      ENSMMUP00000032870.3, ENSMMUT00000013449.4
      Conserved Domains (4) summary
      cd01080
      Location:228 → 399
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:417 → 1042
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:114 → 401
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:114 → 233
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    2. XM_028851609.1 → XP_028707442.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      F7BMX8
      Conserved Domains (2) summary
      cd01080
      Location:1 → 111
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:129 → 754
      PLN02759; Formate--tetrahydrofolate ligase
    Nucleotide Protein
    Heading Accession and Version

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