SARM1 sterile alpha and TIR motif containing 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SARM1provided by VGNC
Official Full Name: sterile alpha and TIR motif containing 1provided by VGNC
Primary source: VGNC:VGNC:104648
See related: Ensembl:ENSMMUG00000061478
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (23990713..24016533)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (22368984..22396659)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.
Title: Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.

Submit: New GeneRIF Correction

General gene information

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Markers

RH11530 (e-PCR)
- UniSTS:90701

RH39314 (e-PCR)
- UniSTS:91818

SHGC-57890 (e-PCR)
- UniSTS:74184

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD(+) hydrolase SARM1; sterile alpha and TIR motif-containing protein 1

NP_001252642.1

EC 3.2.2.6

XP_028691539.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001265713.1 → NP_001252642.1 NAD(+) hydrolase SARM1 precursor

See identical proteins and their annotated locations for NP_001252642.1

Status: PROVISIONAL

Source sequence(s)

JV600183

UniProtKB/TrEMBL

F6UL84, G7NGJ2

Related

ENSMMUP00000062689.1, ENSMMUT00000107642.1

Conserved Domains (4) summary

cd09501
Location:409 → 477

SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1

cd09502
Location:478 → 547

SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2

smart00454
Location:409 → 476

SAM; Sterile alpha motif

smart00255
Location:561 → 702

TIR; Toll - interleukin 1 - resistance

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041769.1 Reference Mmul_10 Primary Assembly

Range

23990713..24016533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028835706.1 → XP_028691539.1 sterile alpha and TIR motif-containing protein 1 isoform X1

Conserved Domains (3) summary

cd09501
Location:409 → 477

SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1

cd09502
Location:478 → 547

SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2

cl23749
Location:561 → 633

TIR_2; TIR domain