APTX aprataxin [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: APTXprovided by VGNC
Official Full Name: aprataxinprovided by VGNC
Primary source: VGNC:VGNC:69838
See related: Ensembl:ENSMMUG00000007724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	15	NC_041768.1 (50883442..50915034)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	15	NC_027907.1 (50949882..50980203)

Chromosome 15 - NC_041768.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH46890 (e-PCR)
- UniSTS:39445

G20636 (e-PCR)
- UniSTS:62782

A005Z44 (e-PCR)
- UniSTS:62783

G32803 (e-PCR)
- UniSTS:117382

AB056422 (e-PCR)
- UniSTS:480150

SHGC-34030 (e-PCR)
- UniSTS:55738

A009S13 (e-PCR)
- UniSTS:15852

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA 5'-adenosine monophosphate hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables single-strand break-containing DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info	PubMed
involved_in single strand break repair	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: aprataxin

NP_001253363.1

EC 3.6.1.71

EC 3.6.1.72

XP_014972868.1

EC 3.6.1.71

EC 3.6.1.72

XP_014972869.1

EC 3.6.1.71

EC 3.6.1.72

XP_014972870.1

EC 3.6.1.71

EC 3.6.1.72

XP_014972871.2

EC 3.6.1.71

EC 3.6.1.72

XP_014972872.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690104.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690105.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690106.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690107.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690109.1

EC 3.6.1.71

EC 3.6.1.72

XP_028690110.1

EC 3.6.1.71

EC 3.6.1.72

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001266434.1 → NP_001253363.1 aprataxin

See identical proteins and their annotated locations for NP_001253363.1

Status: PROVISIONAL

Source sequence(s)

JV047458

UniProtKB/TrEMBL

F7C967, H9FW73, H9YUS5

Related

ENSMMUP00000010149.3, ENSMMUT00000010819.4

Conserved Domains (3) summary

cd01278
Location:178 → 279

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:297 → 356

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:19 → 115

FHA_2; FHA domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041768.1 Reference Mmul_10 Primary Assembly

Range

50883442..50915034

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015117385.2 → XP_014972871.2 aprataxin isoform X4

UniProtKB/TrEMBL

H9FW73

Conserved Domains (3) summary

cd01278
Location:136 → 237

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:255 → 314

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:31 → 70

FHA_2; FHA domain
XM_028834271.1 → XP_028690104.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
XM_015117383.2 → XP_014972869.1 aprataxin isoform X2

UniProtKB/TrEMBL

F7C3I2, F7C3L9

Related

ENSMMUP00000010162.4, ENSMMUT00000010832.4

Conserved Domains (3) summary

cd01278
Location:164 → 265

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:283 → 342

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:5 → 101

FHA_2; FHA domain
XM_028834276.1 → XP_028690109.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
XM_015117386.2 → XP_014972872.1 aprataxin isoform X5

UniProtKB/TrEMBL

F7C3I2

Conserved Domains (3) summary

cd01278
Location:110 → 211

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:229 → 288

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:5 → 44

FHA_2; FHA domain
XM_015117382.2 → XP_014972868.1 aprataxin isoform X1

UniProtKB/TrEMBL

H9FW73

Conserved Domains (3) summary

cd01278
Location:186 → 287

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:305 → 364

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:27 → 123

FHA_2; FHA domain
XM_015117384.2 → XP_014972870.1 aprataxin isoform X3

UniProtKB/TrEMBL

H9FW73

Conserved Domains (3) summary

cd01278
Location:132 → 233

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:251 → 310

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

pfam17913
Location:27 → 66

FHA_2; FHA domain
XM_028834274.1 → XP_028690107.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
XM_028834272.1 → XP_028690105.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
XM_028834273.1 → XP_028690106.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
XM_028834277.1 → XP_028690110.1 aprataxin isoform X6

Conserved Domains (2) summary

cd01278
Location:76 → 177

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

pfam16278
Location:195 → 254

zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger