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    FGD3 FYVE, RhoGEF and PH domain containing 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706720, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGD3provided by VGNC
    Official Full Name
    FYVE, RhoGEF and PH domain containing 3provided by VGNC
    Primary source
    VGNC:VGNC:72512
    See related
    Ensembl:ENSMMUG00000020795
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FGD3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (107911200..107999309)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (43074922..43163192)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene BICD cargo adaptor 2 Neighboring gene uncharacterized LOC106993693 Neighboring gene uncharacterized LOC114672849 Neighboring gene sushi domain containing 3 Neighboring gene uncharacterized LOC106993688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 3
    Names
    glucocorticoid deficiency 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      107911200..107999309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028835335.1 → XP_028691168.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Related
      ENSMMUP00000027371.4, ENSMMUT00000029253.4
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    2. XM_028835334.1 → XP_028691167.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    3. XM_015117271.2 → XP_014972757.2  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    4. XM_028835333.1 → XP_028691166.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    5. XM_015117273.2 → XP_014972759.2  FYVE, RhoGEF and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:609 → 713
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    6. XM_001104111.4 → XP_001104111.2  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Related
      ENSMMUP00000038783.3, ENSMMUT00000045738.3
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    7. XM_028835336.1 → XP_028691169.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins

    8. XM_028835337.1 → XP_028691170.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F6W261, F7H9V6, G7NF21
      Conserved Domains (4) summary
      cd00160
      Location:160 → 339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:610 → 714
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd13387
      Location:371 → 478
      PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
      cd15740
      Location:531 → 584
      FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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