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    FARP2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701179, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FARP2provided by VGNC
    Official Full Name
    FERM, ARH/RhoGEF and pleckstrin domain protein 2provided by VGNC
    Primary source
    VGNC:VGNC:72513
    See related
    Ensembl:ENSMMUG00000001313
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FARP2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (128783259..128931913)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (124214782..124362317)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC114671465 Neighboring gene septin 2 Neighboring gene BTB/POZ domain-containing protein KCTD5 pseudogene Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene translation initiation factor IF-2-like Neighboring gene serine/threonine kinase 25 Neighboring gene uncharacterized LOC106992799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FERM, RhoGEF and pleckstrin domain-containing protein 2; FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    FERM, RhoGEF and pleckstrin domain protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      128783259..128931913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111550.2 → XP_014967036.2  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7BN41, H9G2J8
      Conserved Domains (7) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      PHA03307
      Location:358 → 528
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:538 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:750 → 856
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:929 → 1026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:334 → 375
      FA; FERM adjacent (FA)

    2. XM_001091489.4 → XP_001091489.3  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7BN41, H9G2J8
      Related
      ENSMMUP00000001751.4, ENSMMUT00000001856.4
      Conserved Domains (7) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      PHA03307
      Location:358 → 528
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:538 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:750 → 856
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:929 → 1026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:334 → 375
      FA; FERM adjacent (FA)

    3. XM_028831360.1 → XP_028687193.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7BN41, H9G2J8
      Related
      ENSMMUP00000080294.1, ENSMMUT00000108776.1
      Conserved Domains (7) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      PHA03307
      Location:358 → 528
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:538 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:750 → 856
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:929 → 1026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:334 → 375
      FA; FERM adjacent (FA)

    4. XM_015111553.2 → XP_014967039.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AIZ7
      Related
      ENSMMUP00000077882.1, ENSMMUT00000102700.1
      Conserved Domains (9) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      cd00160
      Location:538 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:750 → 856
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      pfam00169
      Location:758 → 852
      PH; PH domain
      pfam00373
      Location:131 → 234
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 375
      FA; FERM adjacent (FA)
      pfam09379
      Location:48 → 111
      FERM_N; FERM N-terminal domain
      pfam15736
      Location:445 → 528
      DUF4684; Domain of unknown function (DUF4684)

    5. XM_015111551.2 → XP_014967037.2  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7BN41, H9G2J8
      Conserved Domains (7) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      PHA03307
      Location:358 → 528
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:538 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:750 → 856
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:929 → 1026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:334 → 375
      FA; FERM adjacent (FA)
    Nucleotide Protein
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