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    Mcee methylmalonyl CoA epimerase [ Mus musculus (house mouse) ]

    Gene ID: 73724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mceeprovided by MGI
    Official Full Name
    methylmalonyl CoA epimeraseprovided by MGI
    Primary source
    MGI:MGI:1920974
    See related
    Ensembl:ENSMUSG00000033429 AllianceGenome:MGI:1920974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110007A04Rik
    Summary
    Predicted to enable methylmalonyl-CoA epimerase activity. Predicted to be involved in L-methylmalonyl-CoA metabolic process. Located in mitochondrion. Is expressed in central nervous system; choroid plexus; and nervous system. Orthologous to human MCEE (methylmalonyl-CoA epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 21.9), kidney adult (RPKM 21.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcee in Genome Data Viewer
    Location:
    7 34.65 cM; 7 C
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (64042370..64061869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64392622..64412121)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19038 Neighboring gene STARR-seq mESC enhancer starr_19039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71537088-71537271 Neighboring gene STARR-positive B cell enhancer ABC_E4931 Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) Neighboring gene SET translocation pseudogene Neighboring gene FANCD2/FANCI-associated nuclease 1 Neighboring gene STARR-seq mESC enhancer starr_19041 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene STARR-seq mESC enhancer starr_19042 Neighboring gene STARR-seq mESC enhancer starr_19043 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene STARR-seq mESC enhancer starr_19044 Neighboring gene STARR-seq mESC enhancer starr_19045 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonyl-CoA epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylmalonyl-CoA epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonyl-CoA epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methylmalonyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methylmalonyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methylmalonyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    methylmalonyl-CoA epimerase, mitochondrial
    Names
    DL-methylmalonyl-CoA racemase
    NP_001342053.1
    NP_082902.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355124.1 → NP_001342053.1  methylmalonyl-CoA epimerase, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC129199
      Consensus CDS
      CCDS90248.1
      UniProtKB/TrEMBL
      A0A0U1RQ27
      Related
      ENSMUSP00000146220.2, ENSMUST00000206194.2
      Conserved Domains (1) summary
      cl14632
      Location:49 → 123
      VOC; vicinal oxygen chelate (VOC) family

    2. NM_028626.2 → NP_082902.1  methylmalonyl-CoA epimerase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_082902.1

      Status: VALIDATED

      Source sequence(s)
      AC129199
      Consensus CDS
      CCDS21334.1
      UniProtKB/Swiss-Prot
      Q9D1I5
      Related
      ENSMUSP00000047855.9, ENSMUST00000037205.11
      Conserved Domains (1) summary
      TIGR03081
      Location:49 → 177
      metmalonyl_epim; methylmalonyl-CoA epimerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      64042370..64061869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1I5.1 GenPept UniProtKB/Swiss-Prot:Q9D1I5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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