Ceacam5 CEA cell adhesion molecule 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ceacam5provided by MGI
Official Full Name: CEA cell adhesion molecule 5provided by MGI
Primary source: MGI:MGI:1920500
See related: Ensembl:ENSMUSG00000008789 AllianceGenome:MGI:1920500
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Psg30; 1600029H12Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including T cell activation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in apical plasma membrane; cell surface; and cytosol. Predicted to be active in external side of plasma membrane. Orthologous to human CEACAM7 (CEA cell adhesion molecule 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 159.5) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 A2; 7 9.15 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (17447141..17495046)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (17713216..17761121)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.
Title: SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.
a new mechanistic insight into how the CEA IgV-like N domain participates in cellular events that can have a macroscopic impact in terms of cancer progression and metastasis.
Title: The carcinoembryonic antigen IgV-like N domain plays a critical role in the implantation of metastatic tumor cells.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cell adhesion molecule CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5

Names: pregnancy-specific glycoprotein 30

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028480.2 → NP_082756.1 cell adhesion molecule CEACAM5 precursor

See identical proteins and their annotated locations for NP_082756.1

Status: PROVISIONAL

Source sequence(s)

AK145976

Consensus CDS

CCDS20863.1

UniProtKB/Swiss-Prot

Q3UKK2

Related

ENSMUSP00000080582.7, ENSMUST00000081907.8

Conserved Domains (4) summary

cd05774
Location:393 → 496

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00408
Location:872 → 933

IGc2; Immunoglobulin C-2 Type

smart00410
Location:865 → 944

IG_like; Immunoglobulin like

cl11960
Location:510 → 614

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

17447141..17495046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540389.3 → XP_006540452.1 carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

Conserved Domains (3) summary

smart00408
Location:754 → 815

IGc2; Immunoglobulin C-2 Type

cd05774
Location:630 → 733

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cl11960
Location:510 → 614

Ig; Immunoglobulin domain