Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufb11provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit B11provided by MGI
Primary source: MGI:MGI:1349919
See related: Ensembl:ENSMUSG00000031059 AllianceGenome:MGI:1349919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Np15; p15.6; NP15.6; CI-ESSS; D5Bwg0566e; D5Bwg0577e
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; sensory organ; and trunk mesenchyme. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 152.9), kidney adult (RPKM 110.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.11 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20481565..20483858, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20615326..20617619, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation.
Title: Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufb11 (e-PCR), detects polymorphism
- UniSTS:498527

Ndufb11 (e-PCR), detects polymorphism
- UniSTS:498528

D5Bwg0566e (e-PCR), detects polymorphism
- UniSTS:142535

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11; NADH-ubiquinone oxidoreductase ESSS subunit; complex I-ESSS; neuronal protein 15.6; nuclear protein 15.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358624.1 → NP_001345553.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Status: VALIDATED

Source sequence(s)

AL672073

Consensus CDS

CCDS53012.1

UniProtKB/Swiss-Prot

O09111

UniProtKB/TrEMBL

Q4VBC9

Conserved Domains (1) summary

pfam10183
Location:22 → 139

ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
NM_019435.5 → NP_062308.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

See identical proteins and their annotated locations for NP_062308.2

Status: VALIDATED

Source sequence(s)

AK028121, AL672073

Consensus CDS

CCDS53012.1

UniProtKB/Swiss-Prot

O09111

UniProtKB/TrEMBL

Q4VBC9

Related

ENSMUSP00000112320.2, ENSMUST00000116621.2

Conserved Domains (1) summary

pfam10183
Location:22 → 139

ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)