Orm3 orosomucoid 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Orm3provided by MGI
Official Full Name: orosomucoid 3provided by MGI
Primary source: MGI:MGI:97445
See related: Ensembl:ENSMUSG00000028359 AllianceGenome:MGI:97445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Agp-3; Orm-3
Summary: Predicted to enable small molecule binding activity. Predicted to be involved in acute-phase response and regulation of immune system process. Predicted to be active in extracellular space. Orthologous to several human genes including ORM2 (orosomucoid 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 2.8), subcutaneous fat pad adult (RPKM 2.0) and 7 other tissues See more
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Genomic context

Location:: 4 B3; 4 33.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63274107..63277748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63356069..63359506)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-1-acid glycoprotein 3

Names: AGP 3; OMD 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379520.1 → NP_001366449.1 alpha-1-acid glycoprotein 3 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL683828

UniProtKB/TrEMBL

B7ZP06, B9EIY6

Conserved Domains (1) summary

cd19451
Location:21 → 195

lipocalin_AGP-like; alpha1-acid glycoprotein and similar proteins
NM_001379521.1 → NP_001366450.1 alpha-1-acid glycoprotein 3 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL683828
NM_013623.3 → NP_038651.2 alpha-1-acid glycoprotein 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_038651.2

Status: VALIDATED

Source sequence(s)

AL683828

Consensus CDS

CCDS18252.1

UniProtKB/TrEMBL

B7ZP06, J3JRU4

Related

ENSMUSP00000006687.5, ENSMUST00000006687.5

Conserved Domains (1) summary

pfam00061
Location:40 → 180

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

NR_166739.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL683828
NR_166740.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL683828

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

63274107..63277748

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537666.5 → XP_006537729.1 alpha-1-acid glycoprotein 3 isoform X1

Conserved Domains (1) summary

cl10502
Location:21 → 182

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
XM_006537669.5 → XP_006537732.1 alpha-1-acid glycoprotein 3 isoform X3

Conserved Domains (1) summary

cl10502
Location:21 → 146

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
XM_036163822.1 → XP_036019715.1 alpha-1-acid glycoprotein 3 isoform X4

UniProtKB/Swiss-Prot

Q63805

Conserved Domains (1) summary

cl10502
Location:21 → 159

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
XM_006537667.4 → XP_006537730.1 alpha-1-acid glycoprotein 3 isoform X2

Conserved Domains (1) summary

cl10502
Location:18 → 162

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family