Qrfp pyroglutamylated RFamide peptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Qrfpprovided by MGI
Official Full Name: pyroglutamylated RFamide peptideprovided by MGI
Primary source: MGI:MGI:3630329
See related: Ensembl:ENSMUSG00000043102 AllianceGenome:MGI:3630329
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P518
Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides QRFP-26 (26RFa) and the N-terminally extended form, QRFP-43 (43RFa). Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake. [provided by RefSeq, Sep 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.89 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31696180..31700592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (31806168..31810580, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).
Title: Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).
Role of pyroglutamylated RFamide peptide43 in germ cell dynamics in mice testes in relation to energy metabolism.
Title: Role of pyroglutamylated RFamide peptide43 in germ cell dynamics in mice testes in relation to energy metabolism.
The production and release kinetics of 26RFa after an oral glucose challenge is profoundly altered in the high-fat mice. Altogether, the present findings support the view that 26RFa is a key regulator of glucose homeostasis whose activity is markedly altered under obese/hyperglycemic conditions.
Title: Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice.
Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development
Title: Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development.
QRFP is an important downstream mediator of the arcuate nucleus and regulates feeding behavior, mood, wakefulness and activity.
Title: QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.
26RFa attenuates the hyperglycemia induced by a glucose load, potentiates insulin sensitivity, and increases plasma insulin concentrations.
Title: Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.
Macrophage-conditioned medium containing increased amounts of QRFP preserves adipogenesis in adipocytes.
Title: Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.
The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat.
Title: Hypothalamic QRFP: regulation of food intake and fat selection.
Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
Title: GPR103b functions in the peripheral regulation of adipogenesis.
Qrfp polymorphisms is associated with osteopenia
Title: P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables orexigenic neuropeptide QRFP receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables orexigenic neuropeptide QRFP receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in grooming behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotory behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: orexigenic neuropeptide QRFP

Names: P518 precursor protein (P518)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.