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    Unkl unkempt family like zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 74154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unklprovided by MGI
    Official Full Name
    unkempt family like zinc fingerprovided by MGI
    Primary source
    MGI:MGI:1921404
    See related
    Ensembl:ENSMUSG00000015127 AllianceGenome:MGI:1921404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300004G08Rik
    Summary
    Predicted to enable metal ion binding activity and transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol. Is expressed in ganglia and liver lobe. Orthologous to human UNKL (unk like zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.9), liver E14.5 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unkl in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25407336..25453417)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25188361..25234443)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 154 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. Avet-Rochex A, et al. PLoS Genet, 2014 Sep. PMID 25210733, Free PMC Article
    2. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Vinsland E, et al. Sci Rep, 2021 Aug 11. PMID 34381067, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102273

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase UNKL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197024.1 → NP_001183953.1  putative E3 ubiquitin-protein ligase UNKL isoform 1

      See identical proteins and their annotated locations for NP_001183953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK004898, BC059910, CJ068427
      Consensus CDS
      CCDS57058.1
      UniProtKB/Swiss-Prot
      Q5FWH2, Q6RUT6, Q9DBK4
      Related
      ENSMUSP00000039670.6, ENSMUST00000039734.12
      Conserved Domains (3) summary
      pfam00642
      Location:286 → 310
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:564 → 638
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:684 → 721
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_001290736.1 → NP_001277665.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

      See identical proteins and their annotated locations for NP_001277665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC130711, BC059910
      Consensus CDS
      CCDS70769.1
      UniProtKB/TrEMBL
      E0CYD7
      Related
      ENSMUSP00000124276.2, ENSMUST00000160896.8
      Conserved Domains (3) summary
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:498 → 535
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:387 → 448
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    3. NM_001357876.1 → NP_001344805.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130711
      Conserved Domains (3) summary
      pfam00642
      Location:286 → 310
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:608 → 645
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl27210
      Location:495 → 563
      Mnd1; Mnd1 family

    4. NM_001357877.1 → NP_001344806.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130711
      Consensus CDS
      CCDS70769.1
      UniProtKB/TrEMBL
      E0CYD7
      Conserved Domains (3) summary
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:498 → 535
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:387 → 448
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    5. NM_028789.3 → NP_083065.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

      See identical proteins and their annotated locations for NP_083065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC130711
      Consensus CDS
      CCDS28510.1
      UniProtKB/TrEMBL
      B9EKD9
      Related
      ENSMUSP00000015271.6, ENSMUST00000015271.12
      Conserved Domains (2) summary
      cl17238
      Location:196 → 233
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:85 → 146
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25407336..25453417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525022.5 → XP_006525085.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

      Conserved Domains (4) summary
      cd00162
      Location:601 → 635
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00642
      Location:286 → 310
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18384
      Location:25 → 60
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
      cl17238
      Location:599 → 636
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_011246684.3 → XP_011244986.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

      See identical proteins and their annotated locations for XP_011244986.1

      UniProtKB/TrEMBL
      E0CYD7
      Conserved Domains (3) summary
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:498 → 535
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:387 → 448
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    3. XM_030250117.1 → XP_030105977.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      UniProtKB/TrEMBL
      B9EKD9
      Conserved Domains (2) summary
      cl17238
      Location:188 → 225
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:77 → 138
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    4. XM_030250116.1 → XP_030105976.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      UniProtKB/TrEMBL
      B9EKD9
      Conserved Domains (2) summary
      cl17238
      Location:188 → 225
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:77 → 138
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    5. XM_030250114.1 → XP_030105974.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

      Conserved Domains (4) summary
      cd00162
      Location:424 → 458
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:422 → 459
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:311 → 372
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    6. XM_030250112.1 → XP_030105972.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

      UniProtKB/TrEMBL
      E0CYD7
      Conserved Domains (3) summary
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:498 → 535
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:387 → 448
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    7. XM_030250113.2 → XP_030105973.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

      Conserved Domains (4) summary
      cd00162
      Location:424 → 458
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:422 → 459
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:311 → 372
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    8. XM_030250111.2 → XP_030105971.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

      UniProtKB/TrEMBL
      E0CYD7
      Conserved Domains (3) summary
      pfam00642
      Location:100 → 124
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:498 → 535
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:387 → 448
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    9. XM_017317696.2 → XP_017173185.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

      Conserved Domains (4) summary
      cd00162
      Location:552 → 586
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00642
      Location:228 → 252
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl17238
      Location:550 → 587
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:439 → 500
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    10. XM_030250115.2 → XP_030105975.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

      UniProtKB/TrEMBL
      B9EKD9
      Conserved Domains (2) summary
      cl17238
      Location:196 → 233
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:85 → 146
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    11. XM_036160816.1 → XP_036016709.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

      Conserved Domains (2) summary
      cd16772
      Location:272 → 309
      RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
      cl26597
      Location:161 → 222
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    12. XM_006525024.4 → XP_006525087.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

      Conserved Domains (2) summary
      cd16772
      Location:272 → 309
      RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
      cl26597
      Location:161 → 222
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    13. XM_017317697.1 → XP_017173186.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      UniProtKB/TrEMBL
      B9EKD9
      Conserved Domains (2) summary
      cl17238
      Location:188 → 225
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:77 → 138
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    14. XM_017317698.2 → XP_017173187.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      UniProtKB/TrEMBL
      B9EKD9
      Conserved Domains (2) summary
      cl17238
      Location:188 → 225
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl26597
      Location:77 → 138
      DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

    RNA

    1. XR_003952197.1 RNA Sequence

    2. XR_004939592.1 RNA Sequence

    3. XR_003952198.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWH2.2 GenPept UniProtKB/Swiss-Prot:Q5FWH2

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