Panx2 pannexin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Panx2provided by MGI
Official Full Name: pannexin 2provided by MGI
Primary source: MGI:MGI:1890615
See related: Ensembl:ENSMUSG00000058441 AllianceGenome:MGI:1890615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable gap junction channel activity and structural molecule activity. Acts upstream of or within response to ischemia. Located in cytoplasm. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; sensory organ; and skeleton. Orthologous to human PANX2 (pannexin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 33.7), cortex adult (RPKM 21.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (88941797..88957769)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89059057..89073566)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes.
Title: Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes.
Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells.
Title: Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.
It used overlap-extension cloning to create the first chimeric Panx, consisting of Panx2 with the Panx1 C-terminus (Panx2(Panx1CT)), to determine whether the Panx1 C-terminus influences the trafficking of Panx2.
Title: Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization.
). Pannexin double-knockout mice (Px1(-/-) Px2(-/-)) were less impaired in parameters such as exploration, anxiety, sensorimotor function and behavioral symmetry.
Title: Functional outcome of pannexin-deficient mice after cerebral ischemia.
In situ hybridization revealed that mRNAs for Panx1 and Panx2 were both expressed in the olfactory epithelium and olfactory bulb.
Title: Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb.
Px1 and Px2 underlie channel function in neurons and contribute to ischemic brain damage
Title: Pannexins in ischemia-induced neurodegeneration.
Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment
Title: Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment.
Panx2 strongly interacts with the core and high-mannose species of Panx1 but not with Panx3. The combination of Panx1 & Panx2 results in compromised channel function.
Title: Glycosylation regulates pannexin intermixing and cellular localization.
Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
Title: Identification and characterization of pannexin expression in the mammalian cochlea.
Data show that Panx2 is expressed in the spiral and Scarpa's ganglion neurons.
Title: Pannexins are new molecular candidates for assembling gap junctions in the cochlea.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gap junction channel activity	ISO Inferred from Sequence Orthology more info
NOT enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pannexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.