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    Kctd17 potassium channel tetramerisation domain containing 17 [ Mus musculus (house mouse) ]

    Gene ID: 72844, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kctd17provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 17provided by MGI
    Primary source
    MGI:MGI:1920094
    See related
    Ensembl:ENSMUSG00000033287 AllianceGenome:MGI:1920094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900008M13Rik
    Summary
    Predicted to enable cullin family protein binding activity; identical protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; positive regulation of cilium assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myoclonic dystonia 26. Orthologous to human KCTD17 (potassium channel tetramerization domain containing 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 65.0), adrenal adult (RPKM 57.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kctd17 in Genome Data Viewer
    Location:
    15 E1; 15 37.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78312578..78323503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78428564..78439303)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52185 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355 Neighboring gene transmembrane serine protease 6 Neighboring gene STARR-positive B cell enhancer ABC_E8598 Neighboring gene STARR-seq mESC enhancer starr_39146 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78306098-78306207 Neighboring gene interleukin 2 receptor, beta chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization. Oh AR, et al. Gastroenterology, 2023 Mar. PMID 36402191, Free PMC Article
    2. Kctd17-mediated Chop degradation promotes adipogenic differentiation. Shin MC, et al. Biochem Biophys Res Commun, 2023 Apr 23. PMID 36868076
    3. Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Kim K, et al. Gastroenterology, 2017 Dec. PMID 28859855, Free PMC Article
    4. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kctd17-mediated Chop degradation promotes adipogenic differentiation.
      Title: Kctd17-mediated Chop degradation promotes adipogenic differentiation.
    2. Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization.
      Title: Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization.
    3. KCTD17, which is up-regulated in liver tissues of obese mice and patients with NAFLD, binds to phosphorylated PHLPP2 to target it for ubiquitin-mediated degradation; this increases expression of genes that regulate lipogenesis to promote hepatic steatosis.
      Title: Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289671.2 → NP_001276600.2  BTB/POZ domain-containing protein KCTD17 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL590144
      Consensus CDS
      CCDS79384.1
      UniProtKB/TrEMBL
      E0CYD2
      Related
      ENSMUSP00000124290.3, ENSMUST00000162517.9
      Conserved Domains (1) summary
      cd18391
      Location:24 → 124
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    2. NM_001289672.2 → NP_001276601.2  BTB/POZ domain-containing protein KCTD17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL590144
      Consensus CDS
      CCDS79385.1
      UniProtKB/TrEMBL
      A6H697, F6SYN4
      Related
      ENSMUSP00000133210.4, ENSMUST00000166142.11
      Conserved Domains (1) summary
      cd18391
      Location:24 → 124
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    3. NM_001289673.2 → NP_001276602.2  BTB/POZ domain-containing protein KCTD17 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL590144
      UniProtKB/TrEMBL
      E0CZ97
      Related
      ENSMUSP00000125574.2, ENSMUST00000159771.8
      Conserved Domains (1) summary
      cd18391
      Location:24 → 124
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    RNA

    1. NR_110357.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons and uses an alternate penultimate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL590144

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78312578..78323503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521460.5 → XP_006521523.3  BTB/POZ domain-containing protein KCTD17 isoform X1

      Conserved Domains (1) summary
      cd18391
      Location:103 → 203
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    2. XM_036159611.1 → XP_036015504.1  BTB/POZ domain-containing protein KCTD17 isoform X2

      Conserved Domains (1) summary
      cd18391
      Location:103 → 203
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    3. XM_006521461.5 → XP_006521524.3  BTB/POZ domain-containing protein KCTD17 isoform X3

      Conserved Domains (1) summary
      cd18391
      Location:103 → 203
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    4. XM_030248792.2 → XP_030104652.2  BTB/POZ domain-containing protein KCTD17 isoform X4

      Conserved Domains (1) summary
      cd18391
      Location:103 → 203
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    RNA

    1. XR_004938873.1 RNA Sequence

    2. XR_004938874.1 RNA Sequence

    3. XR_001781569.3 RNA Sequence

    4. XR_001781568.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081367.1: Suppressed sequence

      Description
      NM_001081367.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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