Tom1l1 target of myb1-like 1 (chicken) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tom1l1provided by MGI
Official Full Name: target of myb1-like 1 (chicken)provided by MGI
Primary source: MGI:MGI:1919193
See related: Ensembl:ENSMUSG00000020541 AllianceGenome:MGI:1919193
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srcasm; 2310045L10Rik
Summary: Enables protein kinase activator activity. Predicted to be involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in endosome and membrane. Is expressed in several structures, including adrenal gland; nervous system; nose; submandibular gland primordium; and vibrissa. Orthologous to human TOM1L1 (target of myb1 like 1 membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 14.0), liver E14.5 (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 55.47 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (90536516..90579105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90645690..90688279, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tom1L1-clathrin heavy chain (CHC) complex negatively regulates the level of SFK in caveolae needed for the induction of DNA synthesis.
Title: The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities.
Srcasm may act as a molecular "rheostat" for activated Src family tyrosine kinases
Title: Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.
Tom1L1 defines a novel mechanism for regulation of Src family of protein-tyrosine kinases mitogenic signaling induced by growth factors.
Title: The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TOM1-like protein 1

Names: Jerry protein; Src activating and signaling molecule; src-activating and signaling molecule protein; target of Myb-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357543.1 → NP_001344472.1 TOM1-like protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI851737, AK033712, AK083630

Consensus CDS

CCDS88221.1

UniProtKB/Swiss-Prot

B0QZV4, Q5SRC7, Q5SRC9, Q923U0, Q99KE0, Q9D6Y5

UniProtKB/TrEMBL

Q7TNI6

Related

ENSMUSP00000020849.3, ENSMUST00000020849.9

Conserved Domains (2) summary

cd14237
Location:198 → 289

GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

cl02544
Location:14 → 154

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001357544.1 → NP_001344473.1 TOM1-like protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AF395837, AI851737, AK009826, AK033712

Consensus CDS

CCDS88220.1

UniProtKB/TrEMBL

Q7TNI6

Related

ENSMUSP00000103501.3, ENSMUST00000107869.9

Conserved Domains (2) summary

cl02544
Location:14 → 125

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

cl03906
Location:124 → 213

GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
NM_001357547.1 → NP_001344476.1 TOM1-like protein 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons, includes an alternate 5' terminal exon and uses a downstream start codon, compared to variant 1. It encodes isoform 4, which is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AI851737, AL672199

Consensus CDS

CCDS88219.1

Related

ENSMUSP00000103499.2, ENSMUST00000107867.8

Conserved Domains (1) summary

cl03906
Location:1 → 42

GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
NM_028011.3 → NP_082287.1 TOM1-like protein 1 isoform 3

See identical proteins and their annotated locations for NP_082287.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AI851737, AK033712

Consensus CDS

CCDS36280.1

UniProtKB/TrEMBL

Q7TNI6, Q8BZR6

Related

ENSMUSP00000103500.2, ENSMUST00000107868.8

Conserved Domains (2) summary

cd14237
Location:121 → 212

GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

cl02544
Location:1 → 77

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

90536516..90579105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534269.4 → XP_006534332.1 TOM1-like protein 1 isoform X1

UniProtKB/TrEMBL

Q7TNI6

Conserved Domains (2) summary

cd16997
Location:14 → 150

VHS_Tom1L1; VHS (Vps27/Hrs/STAM) domain of TOM1-like protein 1

cl03906
Location:164 → 254

GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins