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    Elac2 elaC ribonuclease Z 2 [ Mus musculus (house mouse) ]

    Gene ID: 68626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elac2provided by MGI
    Official Full Name
    elaC ribonuclease Z 2provided by MGI
    Primary source
    MGI:MGI:1890496
    See related
    Ensembl:ENSMUSG00000020549 AllianceGenome:MGI:1890496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpc2; D11Wsu80e; 1110017O07Rik
    Summary
    Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-end processing. Located in mitochondrial nucleoid. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elac2 in Genome Data Viewer
    Location:
    11 B3; 11 40.42 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (64869856..64892906)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (64979030..65002080)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30305 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025 Neighboring gene STARR-seq mESC enhancer starr_29760 Neighboring gene STARR-positive B cell enhancer ABC_E2356 Neighboring gene Rho GTPase activating protein 44 Neighboring gene STARR-seq mESC enhancer starr_29762 Neighboring gene STARR-seq mESC enhancer starr_29763 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene predicted gene, 53042 Neighboring gene peroxiredoxin 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. Stentenbach M, et al. EMBO Mol Med, 2023 Jun 7. PMID 37093546, Free PMC Article
    2. Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z. Siira SJ, et al. EMBO Rep, 2018 Oct. PMID 30126926, Free PMC Article
    3. Mitochondrial gene expression is required for platelet function and blood clotting. Richman TR, et al. Cell Rep, 2023 Nov 28. PMID 37889747
    4. ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA. Liang J, et al. Cells, 2023 Feb 14. PMID 36831280, Free PMC Article
    5. Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity. Elbarbary RA, et al. Biochim Biophys Acta, 2008 Dec. PMID 18809514

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-tRNA processing endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-tRNA processing endoribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc phosphodiesterase ELAC protein 2
    Names
    RNase Z 2
    elaC homolog 2
    elaC homolog protein 2
    putative prostate cancer susceptibility protein
    ribonuclease Z 2
    tRNA 3 endonuclease 2
    tRNase Z 2
    tRNase Z(L)
    NP_001349911.1
    NP_001349912.1
    NP_001349913.1
    NP_075968.2
    XP_006534128.1
    XP_006534129.1
    XP_006534130.1
    XP_006534131.1
    XP_030102124.1
    XP_036012824.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362982.1 → NP_001349911.1  zinc phosphodiesterase ELAC protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663045
      UniProtKB/TrEMBL
      B1ATP7
      Conserved Domains (2) summary
      cd07718
      Location:479 → 689
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52 → 307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

    2. NM_001362983.1 → NP_001349912.1  zinc phosphodiesterase ELAC protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Consensus CDS
      CCDS88171.1
      UniProtKB/TrEMBL
      B1ATP7
      Related
      ENSMUSP00000098610.3, ENSMUST00000101049.9
      Conserved Domains (2) summary
      cd07718
      Location:479 → 684
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52 → 307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

    3. NM_001362984.1 → NP_001349913.1  zinc phosphodiesterase ELAC protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Related
      ENSMUST00000140369.2
      Conserved Domains (1) summary
      cd07718
      Location:111 → 316
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

    4. NM_023479.3 → NP_075968.2  zinc phosphodiesterase ELAC protein 2 isoform 1

      See identical proteins and their annotated locations for NP_075968.2

      Status: VALIDATED

      Source sequence(s)
      AL663045, BC048235
      Consensus CDS
      CCDS24841.1
      UniProtKB/Swiss-Prot
      B1ATP6, Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2
      UniProtKB/TrEMBL
      B1ATP7, Q3U0M8
      Related
      ENSMUSP00000071788.6, ENSMUST00000071891.12
      Conserved Domains (3) summary
      COG1234
      Location:478 → 748
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:479 → 684
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52 → 307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      64869856..64892906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534065.3 → XP_006534128.1  zinc phosphodiesterase ELAC protein 2 isoform X1

      UniProtKB/TrEMBL
      B1ATP7
      Conserved Domains (2) summary
      cd07718
      Location:479 → 689
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52 → 307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

    2. XM_006534067.3 → XP_006534130.1  zinc phosphodiesterase ELAC protein 2 isoform X4

      Conserved Domains (1) summary
      cd07718
      Location:111 → 321
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

    3. XM_006534068.2 → XP_006534131.1  zinc phosphodiesterase ELAC protein 2 isoform X5

      Conserved Domains (1) summary
      cd07718
      Location:111 → 316
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

    4. XM_006534066.4 → XP_006534129.1  zinc phosphodiesterase ELAC protein 2 isoform X2

      UniProtKB/TrEMBL
      B1ATP7
      Conserved Domains (2) summary
      cd07718
      Location:375 → 585
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:1 → 203
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_036156931.1 → XP_036012824.1  zinc phosphodiesterase ELAC protein 2 isoform X4

      Conserved Domains (1) summary
      cd07718
      Location:111 → 321
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

    6. XM_030246264.2 → XP_030102124.1  zinc phosphodiesterase ELAC protein 2 isoform X3

      UniProtKB/TrEMBL
      B1ATP7
      Conserved Domains (2) summary
      cd07718
      Location:375 → 580
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:1 → 203
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y81.1 GenPept UniProtKB/Swiss-Prot:Q80Y81

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