Slc5a4a solute carrier family 5, member 4a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a4aprovided by MGI
Official Full Name: solute carrier family 5, member 4aprovided by MGI
Primary source: MGI:MGI:1927848
See related: Ensembl:ENSMUSG00000020229 AllianceGenome:MGI:1927848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SGLT3-a
Summary: Enables D-glucose:sodium symporter activity and proton transmembrane transporter activity. Acts upstream of or within proton transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC5A4 (solute carrier family 5 member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 18.2), small intestine adult (RPKM 11.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.71 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75983285..76025099)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (76147451..76189265)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of SGLT3a in endometrial epithelial cells induces paracrine stromal cell decidualization.
Title: Activation of SGLT3a in endometrial epithelial cells induces paracrine stromal cell decidualization.
Mouse SGLT3a did not transport sugar.
Title: Mouse SGLT3a generates proton-activated currents but does not transport sugar.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

Slc5a4a (e-PCR), detects polymorphism
- UniSTS:547129

D10Mit174 (e-PCR), detects polymorphism
- UniSTS:126079

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables D-glucose:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hexose transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 5 member 4A

Names: Na(+)/glucose cotransporter 3; low affinity sodium-glucose cotransporter; sodium-dependent glucose cotransporter; sodium/glucose cotransporter 3; solute carrier family 5 member 4; solute carrier family 5, member alpha 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.