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    Hao1 hydroxyacid oxidase 1, liver [ Mus musculus (house mouse) ]

    Gene ID: 15112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hao1provided by MGI
    Official Full Name
    hydroxyacid oxidase 1, liverprovided by MGI
    Primary source
    MGI:MGI:96011
    See related
    Ensembl:ENSMUSG00000027261 AllianceGenome:MGI:96011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GOX; Gox1; Hao-1
    Summary
    Enables (S)-2-hydroxy-acid oxidase activity. Predicted to be involved in fatty acid alpha-oxidation and glycolate catabolic process. Located in peroxisome. Is expressed in alimentary system; gland; liver; and pancreas. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 32.6) and liver adult (RPKM 18.0) See more
    Orthologs
    human all
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    Genomic context

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    See Hao1 in Genome Data Viewer
    Location:
    2 F2; 2 65.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (134339281..134396272, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (134497361..134554352, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39940 Neighboring gene STARR-seq mESC enhancer starr_05765 Neighboring gene STARR-seq mESC enhancer starr_05766 Neighboring gene STARR-seq mESC enhancer starr_05767 Neighboring gene predicted gene, 54132 Neighboring gene STARR-seq mESC enhancer starr_05768 Neighboring gene STARR-seq mESC enhancer starr_05769 Neighboring gene STARR-seq mESC enhancer starr_05770 Neighboring gene predicted gene, 52526 Neighboring gene STARR-positive B cell enhancer mm9_chr2:134469788-134470089 Neighboring gene thioredoxin-related transmembrane protein 4 Neighboring gene predicted gene 14037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HAO1 negatively regulates liver macrophage activation via the NF-κB pathway in alcohol-associated liver disease. Chen H, et al. Cell Signal, 2022 Nov. PMID 35953025
    2. Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling. Shi C, et al. Biochim Biophys Acta, 2013 Mar. PMID 23266618
    3. Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. Kohler SA, et al. J Biol Chem, 1999 Jan 22. PMID 9891009
    4. Identification and expression of a cDNA for human glycolate oxidase. Williams E, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978532
    5. Genetics of hydroxyacid oxidase isozymes in the mouse: localisation of Hao-2 on linkage group XVI. Holmes RS. Heredity (Edinb), 1978 Dec. PMID 284003

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HAO1 negatively regulates liver macrophage activation via the NF-kappaB pathway in alcohol-associated liver disease.
      Title: HAO1 negatively regulates liver macrophage activation via the NF-κB pathway in alcohol-associated liver disease.
    2. Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion.
      Title: Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141211

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (S)-2-hydroxy-acid oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (S)-2-hydroxy-acid oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FMN binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glyoxylate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid alpha-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2-Hydroxyacid oxidase 1
    Names
    HAOX1
    glycolate oxidase 1
    glyoxylate oxidase
    NP_034533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010403.2 → NP_034533.1  2-Hydroxyacid oxidase 1

      See identical proteins and their annotated locations for NP_034533.1

      Status: PROVISIONAL

      Source sequence(s)
      AL845309
      Consensus CDS
      CCDS16783.1
      UniProtKB/Swiss-Prot
      Q9WU19
      UniProtKB/TrEMBL
      Q3UEE8
      Related
      ENSMUSP00000028704.3, ENSMUST00000028704.3
      Conserved Domains (2) summary
      cd02809
      Location:9 → 357
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
      pfam01070
      Location:16 → 362
      FMN_dh; FMN-dependent dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      134339281..134396272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU19.1 GenPept UniProtKB/Swiss-Prot:Q9WU19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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