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    Siah1b siah E3 ubiquitin protein ligase 1B [ Mus musculus (house mouse) ]

    Gene ID: 20438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Siah1bprovided by MGI
    Official Full Name
    siah E3 ubiquitin protein ligase 1Bprovided by MGI
    Primary source
    MGI:MGI:108063
    See related
    Ensembl:ENSMUSG00000040749 AllianceGenome:MGI:108063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sinh1b; siah-1b
    Summary
    This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.7), liver E14.5 (RPKM 6.2) and 28 other tissues See more
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    Genomic context

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    See Siah1b in Genome Data Viewer
    Location:
    X F5; X 76.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162853699..162859489, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164070703..164076493, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene predicted gene, 38561 Neighboring gene carbonic anhydrase 5b, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Fiucci G, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14985507, Free PMC Article
    2. Normal p53 function in primary cells deficient for Siah genes. Frew IJ, et al. Mol Cell Biol, 2002 Dec. PMID 12417719, Free PMC Article
    3. Cloning and characterization of the mouse PIG-A gene. Yu J, et al. Biochim Biophys Acta, 1995 Apr 6. PMID 7734452
    4. Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit. Famulski JK, et al. Science, 2010 Dec 24. PMID 21109632, Free PMC Article
    5. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Della NG, et al. Development, 1993 Apr. PMID 8404535

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SIAH1B
    Names
    RING-type E3 ubiquitin transferase SIAH1B
    drosophila seven-in-absentia gene product homolog
    seven in absentia 1B
    seven in absentia homolog 1b
    NP_001295314.1
    NP_001295315.1
    NP_033199.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308385.1 → NP_001295314.1  E3 ubiquitin-protein ligase SIAH1B

      See identical proteins and their annotated locations for NP_001295314.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL732294, BC052887, CF723667, CJ094899, DV648408
      Consensus CDS
      CCDS30516.1
      UniProtKB/Swiss-Prot
      Q06985, Q7TPV6
      UniProtKB/TrEMBL
      A2AHZ2
      Conserved Domains (1) summary
      pfam03145
      Location:82 → 278
      Sina; Seven in absentia protein family

    2. NM_001308386.1 → NP_001295315.1  E3 ubiquitin-protein ligase SIAH1B

      See identical proteins and their annotated locations for NP_001295315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL732294, BC052887, DV648408
      Consensus CDS
      CCDS30516.1
      UniProtKB/Swiss-Prot
      Q06985, Q7TPV6
      UniProtKB/TrEMBL
      A2AHZ2
      Related
      ENSMUSP00000071592.3, ENSMUST00000071667.9
      Conserved Domains (1) summary
      pfam03145
      Location:82 → 278
      Sina; Seven in absentia protein family

    3. NM_009173.2 → NP_033199.1  E3 ubiquitin-protein ligase SIAH1B

      See identical proteins and their annotated locations for NP_033199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL732294, BC052887, CJ063158, DV648408
      Consensus CDS
      CCDS30516.1
      UniProtKB/Swiss-Prot
      Q06985, Q7TPV6
      UniProtKB/TrEMBL
      A2AHZ2
      Related
      ENSMUSP00000043215.3, ENSMUST00000037928.9
      Conserved Domains (1) summary
      pfam03145
      Location:82 → 278
      Sina; Seven in absentia protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      162853699..162859489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06985.2 GenPept UniProtKB/Swiss-Prot:Q06985

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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