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    ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701400, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARAP3provided by VGNC
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by VGNC
    Primary source
    VGNC:VGNC:69893
    See related
    Ensembl:ENSMMUG00000000465
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARAP3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (139035075..139063578, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (139428892..139457820, complement)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT like 2 Neighboring gene uncharacterized LOC106998972 Neighboring gene protocadherin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      139035075..139063578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141089.2 → XP_014996575.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      G7MVC0
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:12 → 64
      SAM; Sterile alpha motif
      cd04385
      Location:853 → 1028
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:231 → 323
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:340 → 421
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:230 → 321
      PH; PH domain
      pfam00788
      Location:1061 → 1153
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:432 → 548
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:1156 → 1275
      PH-like; Pleckstrin homology-like domain

    2. XM_015141088.2 → XP_014996574.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RDA8, G7MVC0
      Related
      ENSMMUP00000058301.2, ENSMMUT00000060800.2
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:12 → 64
      SAM; Sterile alpha motif
      cd04385
      Location:911 → 1086
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289 → 381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398 → 479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:288 → 379
      PH; PH domain
      pfam01412
      Location:490 → 606
      ArfGap; Putative GTPase activating protein for Arf
      cl00155
      Location:1119 → 1203
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1177 → 1290
      PH-like; Pleckstrin homology-like domain

    3. XM_015141087.2 → XP_014996573.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      F6YQS1
      Related
      ENSMMUP00000000634.4, ENSMMUT00000000685.4
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:12 → 64
      SAM; Sterile alpha motif
      cd04385
      Location:911 → 1086
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289 → 381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398 → 479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:288 → 379
      PH; PH domain
      pfam00788
      Location:1119 → 1211
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:490 → 606
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:1214 → 1333
      PH-like; Pleckstrin homology-like domain

    4. XM_015141085.2 → XP_014996571.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QLW8, G7MVC0
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:12 → 64
      SAM; Sterile alpha motif
      cd04385
      Location:911 → 1086
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289 → 381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398 → 479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:288 → 379
      PH; PH domain
      pfam00788
      Location:1119 → 1211
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:490 → 606
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:1214 → 1333
      PH-like; Pleckstrin homology-like domain

    5. XM_015141090.2 → XP_014996576.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      G7MVC0
      Conserved Domains (7) summary
      cd04385
      Location:833 → 1008
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:211 → 303
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:320 → 401
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:210 → 301
      PH; PH domain
      pfam00788
      Location:1041 → 1133
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:412 → 528
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:1136 → 1255
      PH-like; Pleckstrin homology-like domain

    6. XM_015141086.2 → XP_014996572.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QLW8, G7MVC0
      Related
      ENSMMUP00000049043.2, ENSMMUT00000076305.2
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:12 → 64
      SAM; Sterile alpha motif
      cd04385
      Location:911 → 1086
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289 → 381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398 → 479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:288 → 379
      PH; PH domain
      pfam00788
      Location:1119 → 1211
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:490 → 606
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:1214 → 1333
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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