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    PDGFA platelet derived growth factor subunit A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707725, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDGFAprovided by VGNC
    Official Full Name
    platelet derived growth factor subunit Aprovided by VGNC
    Primary source
    VGNC:VGNC:75926
    See related
    Ensembl:ENSMMUG00000004949
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (33567498..33590664, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (34375275..34398168, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene forkhead box protein L1 Neighboring gene uncharacterized LOC100424078 Neighboring gene uncharacterized LOC106997323 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene dynein axonemal assembly factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      33567498..33590664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845419.1 → XP_028701252.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZL59
      Conserved Domains (2) summary
      smart00141
      Location:139 → 226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:96 → 140
      PDGF_N; Platelet-derived growth factor, N terminal region

    2. XM_028845418.1 → XP_028701251.1  platelet-derived growth factor subunit A isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZL59
      Related
      ENSMMUP00000006558.4, ENSMMUT00000006976.4
      Conserved Domains (2) summary
      smart00141
      Location:139 → 226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:96 → 140
      PDGF_N; Platelet-derived growth factor, N terminal region

    3. XM_028845421.1 → XP_028701254.1  platelet-derived growth factor subunit A isoform X4

      UniProtKB/TrEMBL
      H9FVL5
      Conserved Domains (2) summary
      smart00141
      Location:94 → 181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    4. XM_028845423.1 → XP_028701256.1  platelet-derived growth factor subunit A isoform X6

      UniProtKB/TrEMBL
      A0A1D5R764, H9FVL5, I0FIM9
      Related
      ENSMMUP00000056152.2, ENSMMUT00000070072.2
      Conserved Domains (2) summary
      smart00141
      Location:94 → 181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    5. XM_028845422.1 → XP_028701255.1  platelet-derived growth factor subunit A isoform X5

      UniProtKB/TrEMBL
      F7ERH7
      Conserved Domains (2) summary
      smart00141
      Location:107 → 194
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:34 → 108
      PDGF_N; Platelet-derived growth factor, N terminal region

    6. XM_028845420.1 → XP_028701253.1  platelet-derived growth factor subunit A isoform X3

      Conserved Domains (2) summary
      smart00141
      Location:107 → 194
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:34 → 108
      PDGF_N; Platelet-derived growth factor, N terminal region
    Nucleotide Protein
    Heading Accession and Version

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