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    PAPPA2 pappalysin 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709193, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PAPPA2provided by VGNC
    Official Full Name
    pappalysin 2provided by VGNC
    Primary source
    VGNC:VGNC:75603
    See related
    Ensembl:ENSMMUG00000023214
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PAPPA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (33782176..34087601)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (190717866..191025013, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene COP1 E3 ubiquitin ligase Neighboring gene histone H3.3 Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene protein tyrosine phosphatase type IVA 1-like Neighboring gene astrotactin 1 Neighboring gene microRNA mir-488 Neighboring gene uncharacterized LOC106994726 Neighboring gene BMP/retinoic acid inducible neural specific 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pappalysin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      33782176..34087601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015123561.2 → XP_014979047.2  pappalysin-2

      UniProtKB/TrEMBL
      F7EAV1
      Related
      ENSMMUP00000030555.4, ENSMMUT00000032654.4
      Conserved Domains (6) summary
      cd00033
      Location:1524 → 1590
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00004
      Location:1721 → 1757
      NL; Domain found in Notch and Lin-12
      TIGR02232
      Location:1111 → 1150
      myxo_disulf_rpt; Myxococcus cysteine-rich repeat
      cd04275
      Location:595 → 830
      ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
      pfam00084
      Location:1463 → 1520
      Sushi; Sushi repeat (SCR repeat)
      pfam13385
      Location:281 → 432
      Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    Nucleotide Protein
    Heading Accession and Version

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