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    MITF melanocyte inducing transcription factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695537, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MITFprovided by VGNC
    Official Full Name
    melanocyte inducing transcription factorprovided by VGNC
    Primary source
    VGNC:VGNC:74874
    Locus tag
    EGK_11494
    See related
    Ensembl:ENSMMUG00000002100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MITF in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (125870290..126093861)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (71969832..72193770, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4B Neighboring gene RNA-binding protein 43 pseudogene Neighboring gene histone H1oo pseudogene Neighboring gene translation machinery-associated protein 7 Neighboring gene RNA-binding region-containing protein 3 pseudogene Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microphthalmia-associated transcription factor
    Names
    melanogenesis associated transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266857.1 → NP_001253786.1  microphthalmia-associated transcription factor

      See identical proteins and their annotated locations for NP_001253786.1

      Status: PROVISIONAL

      Source sequence(s)
      JV635527
      UniProtKB/TrEMBL
      A0A5F7ZK21, F6UXQ5, I2CV82
      Related
      ENSMMUP00000002805.4, ENSMMUT00000002969.4
      Conserved Domains (3) summary
      pfam11851
      Location:375 → 488
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:278 → 381
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      125870290..126093861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015130392.2 → XP_014985878.1  microphthalmia-associated transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZK21, A0A8J8YDF0, G7MKW8, H9FUK9
      Conserved Domains (3) summary
      cd18926
      Location:300 → 403
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:397 → 516
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_015130393.2 → XP_014985879.1  microphthalmia-associated transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZK21
      Conserved Domains (3) summary
      cd18926
      Location:299 → 402
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:396 → 515
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_028843104.1 → XP_028698937.1  microphthalmia-associated transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZK21
      Conserved Domains (3) summary
      cd18926
      Location:293 → 396
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:390 → 509
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_015130394.2 → XP_014985880.1  microphthalmia-associated transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A1D5R887, A0A5F7ZK21, H9ELZ8
      Related
      ENSMMUP00000056527.2, ENSMMUT00000072671.2
      Conserved Domains (3) summary
      cd18926
      Location:294 → 397
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:391 → 510
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_015130395.2 → XP_014985881.1  microphthalmia-associated transcription factor isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZK21
      Conserved Domains (3) summary
      pfam11851
      Location:381 → 494
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:284 → 387
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    6. XM_028843105.1 → XP_028698938.1  microphthalmia-associated transcription factor isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZK21
      Conserved Domains (3) summary
      cd18926
      Location:283 → 386
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:380 → 499
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:39 → 177
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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